2020
DOI: 10.1093/noajnl/vdaa073.052
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65. Invasive Histopathology Drives Poor Outcomes in Surgically Resected Brain Metastases

Abstract: BACKGROUND Brain metastasis (BrM) patients treated with surgery and radiotherapy frequently experience local recurrence (LR), leptomeningeal metastasis (LM), and poor overall survival (OS). We sought to correlate the presence of invasive or circumscribed histopathological growth pattern, observed in the BrM lesion and surrounding brain, with these outcomes, and to study molecular mediators of parenchymal invasion. METHODS We … Show more

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