−651C/T promoter polymorphism in the CD14 gene is associated with severity of acute pancreatitis in Japan

Masamune, Atsushi; Kaneda, Kiyoshi; Kikuta, Kazuhiro; Watanabe, Takashi; Hirota, Morihisa; Satoh, Kennichi; Kanno, Atsushi; Suzuki, Noriaki; Kakuta, Yoichi; Shimosegawa, Tooru

doi:10.1007/s00535-009-0163-2

Cited by 11 publications

(11 citation statements)

References 44 publications

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“…Pancreatic tumours are known to be highly hypoxic and hypoxia has been found to induce PSC activity, migration, and activation (51,143,182). Decreased activity and expression of PAK1 in the pancreatic orthotopic tumours in PAK1 KO mouse resulted in increased mouse survival (Fig.…”

Section: Discussionmentioning

confidence: 95%

The Role of p21-Activated Kinases in Pancreatic Cancer

Yeo

Baldwin

et al. 2015

Pancreas

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Pancreatic cancer is an aggressive cancer with a poor prognosis and an overall 5-year survival rate of less than 5%. Management has not improved significantly over the last 30 years, and a better understanding of the genetic and molecular changes that occur is urgently required. Many of these changes appear to involve the p21-activated kinases (PAKs). The PAK family consists of 6 isoforms, 2 of which, PAK1 and PAK4, are up-regulated and/or hyperactivated in pancreatic cancer. p21-Activated kinases can mediate many different cellular processes especially those contributing to cancer development and progression. These processes include the regulation of cytoskeletal dynamics and cell adhesion, the evasion of apoptosis, and the promotion of cell survival, proliferation, migration, and invasion. p21-Activated kinases may also be involved in characteristics unique to pancreatic tumors, such as interplay with the pancreatic stroma, the re-emergence of embryonic pathways, and the involvement of a subset of microRNAs and heat shock proteins. This review highlights the potential role of PAKs in pancreatic cancer and provides a foundation for more effective therapeutics to improve our current treatment of pancreatic cancer.

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Section: Discussionmentioning

confidence: 95%

The Role of p21-Activated Kinases in Pancreatic Cancer

Yeo

Baldwin

et al. 2015

Pancreas

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“…OR, odds ratio; BFDP, Bayesian false-discovery probability; AP, acute pancreatitis; RAP, recurrent acute pancreatitis. Two articles 34,35 reported on the functional c.194+2T>C (IVS3+T>C, rs148954387) variant, but found no association. Meta-analysis of these studies confirmed this association in the overall population (3 studies) (OR 7⋅51, 95 per cent c.i.…”

Section: Serine Protease Inhibitor Kazal Type 1 (Spink1)mentioning

confidence: 99%

Meta-analysis and field synopsis of genetic variants associated with the risk and severity of acute pancreatitis

et al. 2020

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Background: Genetic risk factors can provide insight into susceptibility for acute pancreatitis (AP) and disease progression towards (infected) necrotizing pancreatitis and persistent organ failure. The aim of the study was to undertake a systematic review of the genetic evidence for AP.Methods: Online databases (MEDLINE, Embase, BIOSIS, Web of Science, Cochrane Library) were searched to 8 February 2018. Studies that reported on genetic associations with AP susceptibility, severity and/or complications were eligible for inclusion. Meta-analyses were performed of variants that were reported by at least two data sources. Venice criteria and Bayesian false-discovery probability were applied to assess credibility.Results: Ninety-six studies reporting on 181 variants in 79 genes were identified. In agreement with previous meta-analyses, credible associations were established for SPINK1 (odds ratio (OR) 2⋅87, 95 per cent c.i. 1⋅89 to 4⋅34), IL1B (OR 1⋅23, 1⋅06 to 1⋅42) and IL6 (OR 1⋅64, 1⋅15 to 2⋅32) and disease risk. In addition, two novel credible single-nucleotide polymorphisms were identified in Asian populations: ALDH2 (OR 0⋅48, 0⋅36 to 0⋅64) and IL18 (OR 1⋅47, 1⋅18 to 1⋅82). Associations of variants in TNF, GSTP1 and CXCL8 genes with disease severity were identified, but were of low credibility.Conclusion: Genetic risk factors in genes related to trypsin activation and innate immunity appear to be associated with susceptibility to and severity of AP.All analyses were performed using R studio version 3.3.2 17 . The packages meta and metafor 18 were used

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“…1,2 Genetic factors predisposing for the development and progression of AP are largely unknown. 3,4 Because pancreatic protease/antiprotease plays pivotal roles in the pathogenesis of pancreatitis, genetic studies have focused on this system, especially in patients with chronic pancreatitis (CP). For example, p.R122H (c.365G > A) and p.N29I (c.86A > T) mutations in the cationic trypsinogen (PRSS1) gene are responsible for hereditary pancreatitis.…”

Section: Introductionmentioning

confidence: 99%

Genetic background is different between sentinel and recurrent acute pancreatitis

Masamune

Ariga

Kaneda

et al. 2011

J of Gastro and Hepatol

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−651C/T promoter polymorphism in the CD14 gene is associated with severity of acute pancreatitis in Japan

Abstract: -651C/T promoter polymorphism in the CD14 gene was associated with severity of AP in Japan.

Cited by 11 publications

References 44 publications

The Role of p21-Activated Kinases in Pancreatic Cancer

The Role of p21-Activated Kinases in Pancreatic Cancer

Meta-analysis and field synopsis of genetic variants associated with the risk and severity of acute pancreatitis

Genetic background is different between sentinel and recurrent acute pancreatitis

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