660 Knowledge, Attitude and Practice of Medical Officers in the Treatment of Hypertension in North-Central Zone

Abstract

Background and objective Adrenal vein sampling (AVS) is the gold standard test for identifi cation of unilateral primary aldosteronism (PA) which is curable by surgery, but is a diffi cult procedure with low success rates. Rapid cortisol assays during AVS improved AVS success rates. Design and MethodsWe have developed a gold nanoparticles based immunochromatographic quick cortisol assay (QCA) in which cortisol concentration could be measured semi-quantitatively within 6 minutes. We evaluated the usefulness of semi-quantitative QCA at 4 centers: Kanazawa University Hospital and 3 centers with initial low AVS success rates. We randomly assigned 196 PA patients to undergo AVS using semi-quantitative QCA (semi-quantitative QCA group, n ϭ 99) or AVS without QCA (control group, n ϭ 97). ResultsThe total AVS success rate in the semi-quantitative QCA group at 4 centers was 93 of 99(94%), signifi cantly higher than that in control group (56 of 97 (58%). Even at 3 centers with initial low AVS success rates, the AVS success rate in the semi-quantitative QCA group was 44 of 47(94%), signifi cantly higher than that in control group (23 of 47 (49%)). ConclusionsOur new quick cortisol assay was very fast, simple, and easy and was proved to improve the AVS success rates.