[68 Ga]Ga-PSMA-11 Small Bowel Uptake in Crohn’s Disease: Revisiting the “Non-specificity” of PSMA Ligands

PSMA-Targeted PET Radiotracer [18F]DCFPyL as an Imaging Biomarker in Inflammatory Bowel Disease

“…The use of PSMA-targeted [ 18 F]DCFPyL PET imaging in inflammatory bowel disease has only been reported in a single-case report. 22 This was performed for a patient with rising PSA serology levels in the absence of any genitourinary symptoms. [68 Ga]Ga-PSMA-11 PET/CT was performed, showing uptake in the distal ileum.…”

“…[68 Ga]Ga-PSMA-11 PET/CT was performed, showing uptake in the distal ileum. 22 The patient retrospectively reported a previous diagnosis of Crohn’s disease, with recent increase in diarrheal episodes, bringing the authors to the conclusion that these findings were likely secondary to the patients known history of inflammatory bowel disease. 22 We performed [ 18 F]DCFPyL PET in patients hospitalized due to active IBD to present data that PSMA imaging can be used to noninvasively identify active sites of inflammation in IBD patients during a flare.…”

Hepatic PSMA-Avid Postradiation Inflammation

“…5 Multiple additional incidences of PSMA-avid inflammatory lesions have been reported including PSMA-avid pleural thickening in a patient with newly diagnosed prostate cancer, confirmed by biopsy, surgical mesh from inguinal hernia plug repair mimicking a node, keloids, granulation tissue from heart valves and pleura, proliferative and secretory endometrium, Barrett's mucosa, and inflammatory processes of the abdomen including diverticulosis, Crohn disease, liver sarcoidosis, and anal fistula. [6][7][8][9][10][11] The liver is at risk for radiation-related toxicity within radiation portals of malignancies in the lower thorax and upper abdomen. Radiation-induced liver disease most commonly involves the left and caudate lobes when structures like the distal esophagus are irradiated and can be visualized on FDG PET, 12 like the pattern seen in the current case.…”

“…Further, PSMA expression appears to be upregulated in acute and chronic inflammation including reported PSMA-avid inflammatory hepatic lesions following systemic therapy for metastatic prostate cancer 5. Multiple additional incidences of PSMA-avid inflammatory lesions have been reported including PSMA-avid pleural thickening in a patient with newly diagnosed prostate cancer, confirmed by biopsy, surgical mesh from inguinal hernia plug repair mimicking a node, keloids, granulation tissue from heart valves and pleura, proliferative and secretory endometrium, Barrett's mucosa, and inflammatory processes of the abdomen including diverticulosis, Crohn disease, liver sarcoidosis, and anal fistula [6][7][8][9][10][11]. The liver is at risk for radiation-related toxicity within radiation portals of malignancies in the lower thorax and upper abdomen.…”

68Ga-PSMA PET/CT Uptake in Cutis Verticis Gyrata

“…There are various studies on tissue/diseases with PSMA uptake other than prostate cancer 7,8 . Sarcoidosis, 9 bronchiectasis, 10 periappendicular abscess, 11 Crohn disease, 12 diverticulum, 13 and anal fistula 14 are examples of conditions that show PSMA uptake. To contribute to the literature, we present the PSMA uptake in this CVG case.…”