68Ga-DOTA–Ibandronic Acid PET/CT in a Patient With Chemotherapy-Induced Salivary Gland Hypofunction

Abstract

DOTA–ibandronic acid (IBA) is a novel precursor targeting bone metastasis. It can be radiolabeled with 68Ga for the diagnosis of bone metastases. However, extraosseous lesions can also show increased DOTA-IBA uptake. We report the 68Ga-DOTA-IBA PET/CT findings in a case with cholangiocarcinoma with multiple bone metastases. 68Ga-DOTA-IBA PET/CT revealed increased uptake of DOTA-IBA in bone metastases. Besides, symmetrical and diffuse increased DOTA-IBA uptake in bilateral salivary glands was observed. 99mTcO4 − salivary gland scintigraphy showed impaired salivary gland function.