68Ga-DOTANOC and 18F-FDG PET/CT in metastatic medullary thyroid carcinoma: novel correlations with tumoral biomarkers

Souteiro, Pedro; Gouveia, Petra; Ferreira, Gonçalo Cordeiro; Belo, Sandra; Costa, Cláudia; Carvalho, Davide; Duarte, Hugo; Sampaio, Inês Lucena

doi:10.1007/s12020-019-01846-8

Cited by 19 publications

(20 citation statements)

References 29 publications

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“…On the other hand, although the number of patients in our study was small, we believe that the data presented with the number of lesions are sufficient in terms of the statistical significance. When considering case-based results, although not statistically significant, 68 GaDOTATATE-PET/CT detected a higher number of cases compared to 18 FDG-PET/CT (71.4% vs 57.1%), and this result is consistent with a study by Souteiro et al 6 We think that the small number of patients may be the cause of the lack of statistical significance.…”

Section: Discussionsupporting

confidence: 88%

“…There are studies in the literature comparing PET/CT methods in the follow‐up of operated MTC, and majority of these studies include small‐number patients. Although the number of patients is small too in our study, these patients numbers are similar to the studies in the literature 4–6 . This may be attributed to that MTC is a rarely seen and slowly progressing tumour, PET/CT is not a definitely recognized modality for follow‐up in the existing algorithm, and some PET/CT imaging methods ( 68 GaDOTATATE‐PET/CT, 68Ga‐DOTANOC, 18 F‐DOPA) cannot be widely administered.…”

Section: Discussionsupporting

confidence: 78%

“…CEA can be used in the follow-up of operated MTC as in some tumours, and several studies have reported that elevated CEA is associated with dedifferentiation and poor prognosis in MTC. 3,4,6 In our study, no significant correlation was found between the lesion number with 18 FDG-PET/CT and Ct, while there was a statistically significant positive high correlation with CEA levels. Although all lesions in our study were not histopathologically confirmed, we think that this finding indirectly reveals the association between CEA levels and dedifferentiation in the tumour as specified in the previous studies.…”

Section: Discussioncontrasting

confidence: 66%

“…It was reported that there was no statistically significant difference between both imaging methods in some studies with small patient numbers 6,8,9 , while our study was shown that a higher rate of lesions could be detected with 68 GaDOTATE-PET/CT. This may be attributed that although histological confirmation and differentiation-dedifferentiation distinction were not made in all lesions, MTC is in the neuroendocrine tumour group.…”

Section: Discussioncontrasting

confidence: 59%

“…Although the number of patients is small too in our study, these patients numbers are similar to the studies in the literature. [4][5][6] This may be attributed to that MTC is a rarely seen and slowly progressing tumour, PET/CT is not a definitely recognized modality for follow-up in the existing algorithm, and some PET/CT imaging methods ( 68 GaDO-TATATE-PET/CT, 68Ga-DOTANOC, 18 F-DOPA) cannot be widely administered. On the other hand, although the number of patients in our study was small, we believe that the data presented with the number of lesions are sufficient in terms of the statistical significance.…”

Section: Discussionmentioning

confidence: 99%

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The role of tumour biomarkers in choosing the appropriate positron emission tomography imaging in follow‐up of medullary thyroid cancer

Şahin

Elboğa

2020

J Med Imag Rad Onc

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Introduction: We aimed to demonstrate the importance of serum calcitonin (Ct) and carcinoembryonic-antigen (CEA) levels in the selection of appropriate positron emission tomography/computed tomography (PET/CT) modality in the follow-up of operated patients with medullary thyroid cancer. Methods: Fourteen operated patients (8 Female, 6 Male) with MTC underwent PET/CT imaging with somatostatin (68 Ga-DOTATATE) and glucose (18 FDG) analogs due to elevated Ct or CEA at follow-up. Ct and CEA levels and both PET/CT findings were compared based on both patients and lesions. Results: Positive findings were found in 10 patients with 68 Ga-DOTATATE-PET/ CT and in 8 patients with 18 FDG-PET/CT, and sensitivity was found as 71.4% and 57.1% for both imaging methods, respectively (P > 0.05). Lesion could be detected with 68 Ga-DOTATATE-PET/CT in 3 patients in whom lesion could not be detected with 18 FDG-PET/CT. In one patient, whereas no pathological lesion was with 68 Ga-DOTATATE-PET/CT, lesion could be detected with 18 FDG-PET/CT in this patient. Of the total 67 lesions, 62 could be shown with 68 Ga-DOTATATE-PET/CT, while 48 lesions could be detected with 18 FDG-PET/CT (P < 0.05). A statistically significant positive correlation was found between Ct level and the number of lesions detected on the 68 Ga-DOTATATE-PET/CT, and similarly between CEA level and the number of lesions detected on the 18 FDG-PET/CT. Conclusions: It was found that 68 Ga-DOTATATE-PET/CT is superior over 18 FDG-PET/CT method in detection of recurrent disease in the follow-up of MTC, and serum Ct and CEA levels are important biomarkers in the selection of appropriate PET/CT modality.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 78%