68Ga-FAPI-04 Versus 18F-FDG PET/CT in a Case of Peutz-Jeghers Syndrome

Abstract

Peutz-Jeghers syndrome is a rare inherited hamartomatous polyposis syndrome. We describe 68 Ga-FAPI-04 and 18 F-FDG PET/CT findings in a case of Peutz-Jeghers syndrome with primary duodenal clear cell sarcoma, peritoneal metastases, and multiple intestinal polyps varying in size. The duodenal tumor and its metastases showed increased FDG and FAPI uptake. The peritoneal metastases were delineated more clearly on FAPI PET/CT compared with FDG PET/CT. More interestingly, the intestinal polyps showed increased FDG uptake and no FAPI uptake.

Role of 68Ga-FAPI PET/CT in Screening Malignancy of Familial Adenomatous Polyposis

“…4,5 68 Ga-FAPI-04 PET/CT also comes to fore in colorectal cancers with the absence of physiological or benign causes colonic intense uptake seen in 18 F-FDG PET/CT. [6][7][8] With this case, which is the first in the literature, the popular tumor imaging method of recent years, 68 Ga-FAPI PET/CT, seems to be able to screen the malignancy in FAP patients with high accuracy.…”