[68Ga]Ga-NODAGAZOL uptake in atherosclerotic plaques correlates with the cardiovascular risk profile of patients

Abstract

Conclusion:In this cohort of patients, a positive correlation was noted between atherosclerotic plaque uptake of [ 68 Ga]Ga-NODAGA ZOL and the number of atherogenic risk factors which translates to the risk of atherosclerosis and cardiovascular risk factors.

Bisphosphonates as Radiopharmaceuticals: Spotlight on the Development and Clinical Use of DOTAZOL in Diagnostics and Palliative Radionuclide Therapy

“…Another compound, NODAGA-Zoledronate, also achieved quantitative yields when radiolabeled with 68 Ga [ 142 ] and demonstrated its clinical value in the detection of bone metastases in prostate cancer patients who experienced PSA progression on PSMA-based radioligand therapy or in the setting of restaging [ 143 , 144 ]. NODAGA-Zoledronate also displayed an important uptake in atherosclerotic plaques, which could make it suitable for risk assessment by PET/CT imaging in patients with atherosclerotic cardiovascular disease [ 145 , 146 ]. Lastly, from a radiochemical point of view, it is interesting to note that derivatives with a nine-membered cyclic chelator can be labeled with 18 F via a non-covalent radiofluorination approach that relies on the formation of [ 18 F]aluminum fluoride [ 147 ], as exemplified with [ 18 F]AlF-NOTA-Pamidronate [ 148 ].…”

“…Colloidal gallium-68 should also convert to ionic [ 68 Ga]Ga 3+ due to its extremely low pH, facilitating its subsequent chelation by acetylacetone and its migration to the solvent front. Notably, slightly adapted analytical conditions (e.g., using acetonitrile instead of acetone) have been reported for other 68 Ga-labeled bifunctional bisphosphonates [ 146 ]. To guarantee the reliability of the results obtained by this analysis and to verify that part of the free gallium identified in radio-TLC does not come from the dissociation of the DOTA-complex [ 185 , 186 ], a threeplate TLC system was later proposed in order to more formally identify all the chemical species potentially present [ 178 ].…”

68Ga-bisphosphonates for the imaging of extraosseous calcification by positron emission tomography

“…Nonetheless, [ 18 F]NaF is the only clinically used PET tracer for the imaging of extraosseous calcification 40 , although a recent study has demonstrated the feasibility of the PET BP [ 68 Ga]Ga-NODAGA ZOL for the imaging of EC in atherosclerotic plaques 41 . Given the potentially diverse forms of calcium mineral present in such calcification, we hypothesised that a HAp-selective tracer such as [ 18 F]NaF is not the most appropriate imaging agent for a condition in which HAp may not be the most common form of calcium mineral.…”