68Ga-PSMA Uptake in Pulmonary Tuberculosis: A Pitfall in Prostate Cancer PET Imaging

Liu, Huijuan; Liu, Yuhong; Chen, Yue; Liu, Huipan

doi:10.1055/a-1312-6148

Cited by 3 publications

(1 citation statement)

References 5 publications

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“…151 Incidental uptake of 68 Ga-PSMA on PET/CT imaging in pulmonary and extrapulmonary sites has been reported by others as well. [152][153][154][155] The important takeaway from these reports of 68 Ga-PSMA uptake in TB lesions is for readers to be aware of TB as a possible cause of abnormal radiotracer uptake on 68 Ga PSMA PET/CT scan and to consider this as a differential diagnosis in the suggestive setting (Fig. 10).…”

Section: Targeting Angiogenesis In Tbmentioning

confidence: 99%

Molecular Imaging of Tuberculosis

Lawal

Abubakar²,

Ankrah

et al. 2023

Seminars in Nuclear Medicine

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Section: Targeting Angiogenesis In Tbmentioning

confidence: 99%

Molecular Imaging of Tuberculosis

Lawal

Abubakar²,

Ankrah

et al. 2023

Seminars in Nuclear Medicine

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Synthesis, preclinical, and initial clinical evaluation of integrin αVβ3 and gastrin-releasing peptide receptor (GRPR) dual-targeting radiotracer [68Ga]Ga-RGD-RM26-03

Wen,

Wang,

et al. 2024

Eur J Nucl Med Mol Imaging

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Case report: Systemic tuberculosis with prostate involvement mimicking prostate cancer with multiple metastases on 18F-FDG and 18F-PSMA PET/CT

Sun,

Qiu,

Song

et al. 2024

Front. Med.

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BackgroundProstate tuberculosis is a common form of urogenital tuberculosis that occurs in men. Clinical and imaging manifestations of prostate tuberculosis are atypical, which often need to be differentiated from benign prostatic hyperplasia, a prostate malignant tumor, and a urinary tract infection. Although prostate-specific membrane antigen (PSMA) is considered a specific biomarker for prostate cancer, it is also found within tuberculosis tissues that may be stimulated by angiogenic factors. An abnormal PSMA uptake on positron emission tomography combined with computed tomography (PET/CT) should eliminate the possibility of tuberculosis.Case reportIn this study, we reported a case of a 51-year-old man with an elevated erythrocyte sedimentation rate (ESR) but a normal prostate-specific antigen (PSA) value. 2-Deoxy-2-[fluorine-18]-fluoro-D-glucose (18F-FDG) and [fluorine-18]-prostate-specific membrane antigen (18F-PSMA) PET/CT scans were performed for further evaluation. The prostate showed a high fluoro-D-glucose (FDG) uptake but a slight PSMA uptake. Multiple osteolytic bone destruction and lymph nodes with an increased FDG uptake but a mild PSMA uptake were observed throughout the body. Systemic tuberculosis was diagnosed based on the prostate biopsy and the positive result of the T-cell spot test regarding tuberculosis infection. After 6 months of standard anti-tuberculosis treatment, the patient experienced symptom relief.ConclusionIn the case of a urinary tract infection, where the prostate shows high FDG uptake lesions with perilesional abscess, a mildly increased PSMA uptake, a low PSA value, a high ESR, and relevant clinical symptoms, tuberculosis should be considered and laboratory tests are required, especially when symptoms are relieved after successful anti-tuberculosis therapy. The final confirmation of the diagnosis still relies on pathological examination.

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68Ga-PSMA Uptake in Pulmonary Tuberculosis: A Pitfall in Prostate Cancer PET Imaging

Cited by 3 publications

References 5 publications

Molecular Imaging of Tuberculosis

Molecular Imaging of Tuberculosis

Synthesis, preclinical, and initial clinical evaluation of integrin αVβ3 and gastrin-releasing peptide receptor (GRPR) dual-targeting radiotracer [68Ga]Ga-RGD-RM26-03

Case report: Systemic tuberculosis with prostate involvement mimicking prostate cancer with multiple metastases on 18F-FDG and 18F-PSMA PET/CT

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