“…Males are at higher risks of early onset than females and that this predisposition is related to alienation, anger traits, interaction anxiousness, and prouse beliefs about alcohol (Thomas, 1996). Specifically, during childhood, relatively low intellectual level, poor academic performance, early sexual activity, and depression are found to be the risk factors for early involvement in drug use for females (Fang et al, 2006). Other researchers found early aggressive or shy behavior to be predictive of later heavy substance use status for males, whereas family bonds were found to be predictive of later substance use for females (Ensminger, Brown, & Kellam, 1982).…”