69 Pleurodesis in follow-up and treatment of malignant pleural mesothelioma patients

Ak, Garg; Metintaş, Muzaffer; Yildirim, H.; Erginel, Sinan; Alataş, Füsun; Metintaş, Selma; Dündar, Emine

doi:10.1016/s0169-5002(07)70145-9

Cited by 5 publications

(12 citation statements)

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“…Regarding evaluation of the success rate of chemical pleurodesis among subgroups II and III of the study population, the current study disagreed with Ak et al [29] who evaluated pleurodesis in follow up and treatment of malignant pleural mesothelioma patients and found that pleurodesis succeeded in only 62% of the patients but agreed with Antony et al [21] who stated that pleurodesis studies have demonstrated clinical success rates of 80-85%.…”

Section: Discussioncontrasting

confidence: 88%

Role of epidermal growth factor receptor in malignant pleural mesothelioma and its value for successful chemical pleurodesis

El-Hosainy

Hosny

Gabal

et al. 2014

Egyptian Journal of Chest Diseases and Tuberculosis

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Background: The most common primary malignant tumor of the pleura is malignant mesothelioma. It is a highly aggressive tumor that has become a very important issue over recent years. Evidence suggests that EGFR is involved in the pathogenesis and progression of different carcinomas.Aim of the work: To study the role of EGFR in MPM and to investigate its value for successful chemical pleurodesis.Patients and Methods: This study included 53 patients with exudative pleural effusion. All were subjected to full history taking, clinical examination, CT chest, pleural biopsy histopathological analysis and EGFR Ab immunostaining. According to pleural biopsy histopathology, the patient population was divided into 3 subgroups; subgroup I (19 patients diagnosed benign pleural effusion); subgroup II (21 patients diagnosed MPM) and subgroup III (13 patients diagnosed malignant pleural effusion other than MPM).Results: Regarding comparison between the 3 subgroups in the demographic data, there was no statistically significant difference in age, sex and smoking prevalence. Regarding pleural fluid analysis, there was no statistically significant difference in protein and LDH levels but there was

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Section: Discussioncontrasting

confidence: 88%

Role of epidermal growth factor receptor in malignant pleural mesothelioma and its value for successful chemical pleurodesis

El-Hosainy

Hosny

Gabal

et al. 2014

Egyptian Journal of Chest Diseases and Tuberculosis

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“…Studies have shown that drainage and talc pleurodesis produce excellent symptom control [36]. However, pleurodesis is feasible only when drainage of the pleural effusion achieves full lung expansion [37]. Indwelling, tunneled catheters can be used as an effective alternative to chemical pleurodesis when the lung is entrapped by tumor.…”

Section: Palliative Proceduresmentioning

confidence: 99%

Malignant Pleural Mesothelioma

2011

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Malignant pleural mesothelioma (MPM) is a relatively rare thoracic malignancy accounting for about 2000-3000 new cases per year. This cancer has been increasing in incidence and is strongly associated with asbestos exposure. Also, it is characterized by insidious growth and clinical presentation at an advanced stage of disease. In the past, the treatment of this disease was limited to marginally effective chemotherapy and morbid surgery. This review explores the clinical presentation of MPM, its diagnostic approach and the relevant and recent studies that define the role of chemotherapy, radiation, and various surgical options. Currently, even with aggressive surgical interventions and multimodality strategies, cure remains elusive, although life prolongation has been achieved. Additionally, promising new therapies and interventions that are currently being studied are introduced in this review.

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“…Following duplicate screening of the search results against the exclusion criteria, 170 papers were deemed potentially relevant and retrieved in full for review ( Figure 1). Thirteen reports providing data on 15 different studies (totalling 2,103 patients) were included [4,[6][7][8][9][10][11][12][13][14][15][16][17]; the summary of which is presented in Table 1 and Supplementary Table. Eleven (73.3%) of the included studies were retrospective, three (20%) were prospective observational and a single study (6.7%) was a post-hoc analysis of a clinical trial. Weighted mean age of studied patients was 68.45 (95% CI 67.7 to 69.1) years.…”

Section: Resultsmentioning

confidence: 99%

Survival and pleurodesis outcome in patients with malignant pleural effusion – a systematic review

Hassan

Harriss

Mercer

et al. 2021

Pleura and Peritoneum

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Malignant pleural effusion (MPE) is a common condition that presents with progressive breathlessness. Long term solutions are often required due to recurrence of effusion after simple drainage. Pleurodesis is one of the main options resorted to for long term control of MPE. There is data to suggest there may be a survival benefit for patients with MPE who achieve successful pleurodesis. A systematic review was carried out to explore this correlation and results suggest that there could be a survival difference according to pleurodesis outcome in patients with MPE. Fifteen studies (reported in 13 papers) were included; 13 (86.6%) of the studies showed survival difference in favour of pleurodesis success. The median [interquartile range] difference in survival between the two groups among the different studies was five [3.5–5.8] months. Most of the included studies suffered moderate to severe risk of bias and, thus, large prospective studies of patients undergoing pleurodesis are required to ascertain this effect.

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69 Pleurodesis in follow-up and treatment of malignant pleural mesothelioma patients

Cited by 5 publications

References 0 publications

Role of epidermal growth factor receptor in malignant pleural mesothelioma and its value for successful chemical pleurodesis

Role of epidermal growth factor receptor in malignant pleural mesothelioma and its value for successful chemical pleurodesis

Malignant Pleural Mesothelioma

Survival and pleurodesis outcome in patients with malignant pleural effusion – a systematic review

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