697 Statin induced regression of cardiomyopathy trial (SIRCAT): A randomized, placebo-controlled double-blind trial

New statin use and left ventricular structure: Estimating long‐term associations in the Multi‐Ethnic Study of Atherosclerosis (MESA)

“…Early observational studies in humans have mostly evaluated current or short‐term duration of statin use . Randomized studies of statin use and cardiac structure and/or function have often focused on small populations with cardiovascular diseases including cardiomyopathy, congenital aortic stenosis, and heart failure . These investigations have not consistently demonstrated statin effects on LVM and other indices in addition to having short‐time frames and limited statistical power.…”

“…Early observational studies in humans have mostly evaluated current or short-term duration of statin use. 41,42 Randomized studies of statin use and cardiac structure and/or function have often focused on small populations with cardiovascular diseases including cardiomyopathy, [43][44][45][46][47][48] congenital aortic stenosis, 49 and heart failure. 50 Observational studies and trials in populations similar to MESA (Table 5) have tended to show much larger magnitudes of LVM regression 42,56 or reduced progression of LVM 54 than this investigation.…”