6998 Effects of synthetic prostaglandins e1 and f2a on motility of the sphincter of oddi in humans.

Koshitani, Tatsuya; Kodama, Tadashi; Sato, Hideki; Takaaki, Junpei; Imamura, Yoichi; Kato, Keimei; Wakabayashi, Naoki; Tokita, Kazuhiko; Mitsufuji, Shoji; Kashima, Kei

doi:10.1016/s0016-5107(00)14669-3

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Dysfunction of Oddi's sphincter could be the outcome of loss of myenteric inhibitory neurones resulting in opposing cholinergic tone. The somatostatin analogue, octreotide, and the synthetic prostaglandin E 1 analogue, alprostadil alfadex, reduce the pressure of Oddi's sphincter and might be valuable in the management of the postcholecystectomy syndrome (Fazel et al 2002; Koshitani et al 2002).…”

Section: The Gall Bladdermentioning

confidence: 99%

The Enteric Nervous System II: Gastrointestinal Functions

Hansen

2003

Pharmacology & Toxicology

103

View full text Add to dashboard Cite

Abstract:The enteric nervous system is involved in most of the physiological and pathophysiological processes in the gastrointestinal tract. This Minireview is part two of three and describes the role of the enteric nervous system in gastrointestinal functions (motility, exocrine and endocrine secretions, blood flow, and immune processes) in health and some disease states. In this context, the functional importance of the enteric nervous system for food intake, the gall bladder, and pancreas will be addressed. In specific, dysmotility, diarrhoea, constipation, non-occlusive intestinal ischaemia (intestinal angina), inflammation, cholelithiasis, cholecystitis, postcholecystectomy syndrome, and pancreatitis can be treated with neuroactive pharmacological agents. For example, serotonin receptor type four agonists can be used for the treatment of constipation, while nitric oxide synthesis inhibitors can be employed for the treatment of intestinal angina.

show abstract

Section: The Gall Bladdermentioning

confidence: 99%

The Enteric Nervous System II: Gastrointestinal Functions

Hansen

2003

Pharmacology & Toxicology

103

View full text Add to dashboard Cite

show abstract

“…PGE 1 and PGE 2 induce relaxation of the SO in animals, whereas PGF 2␣ evokes contraction, probably a pharmacologic action. A synthetic prostaglandin E 1 , alprostadil alfadex, markedly reduces sphincter tone and contractile activity in humans undergoing ERCP [28]. This agent may therefore find a therapeutic use in biliary endoscopy or for SO dysfunction.…”

Section: Prostaglandins and L-type Calcium Channel Antagonistsmentioning

confidence: 99%

Effects of bioactive agents on biliary motor function

Woods

Mawe²,

Shaffer³

et al. 2003

Curr Gastroenterol Rep

View full text Add to dashboard Cite

Our understanding of biliary motility under normal and pathophysiologic conditions is still incomplete, but there have been recent advances. Of particular interest are the mechanisms involved in gallbladder filling and emptying, with a focus on understanding the processes underlying impaired gallbladder emptying leading to gallbladder dyskinesia and the formation of gallstones or cholecystitis. The sphincter of Oddi (SO) is a complex neuromuscular structure. Recent studies have attempted to unravel the specific neural or hormonal mechanisms operating under normal physiologic conditions and those that may lead to SO dysfunction. Furthermore, new research fronts are emerging, including the role of leptin in obese patients with impaired biliary motility and the action of electroacupuncture for possible treatment of SO dysfunction. This review illustrates the broad front of current research regarding the effects of bioactive agents on biliary motility, including enteric hormones, nitric oxide, opioids, inflammatory mediators, leptin, protease inhibitors, neurotransmitters, and electroacupuncture.

show abstract

6998 Effects of synthetic prostaglandins e1 and f2a on motility of the sphincter of oddi in humans.

Cited by 2 publications

References 0 publications

The Enteric Nervous System II: Gastrointestinal Functions

The Enteric Nervous System II: Gastrointestinal Functions

Effects of bioactive agents on biliary motor function

Contact Info

Product

Resources

About