2017
DOI: 10.22377/ajp.v11i01.1085
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Abstract: Aim: An attempt has been made to improve drug concentration in the stomach by preparing gastroretentive, swellable, matrix-based sustained release tablets of diltiazem hydrochloride that due to their size would be retained in the upper part of gastrointestinal tract. Materials and Methods: A 3 2 full factorial design was employed for the formulation of expandable tablets; two variables were evaluated. In the present investigation, the amounts of HPMC K100M and sodium carboxymethyl cellulose were selected as in… Show more

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