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Abstract

NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases and improper immune development. The main objective of the present research work was the synthesis of N-(4-{[5-(substituted phenyl)-1,3,4-oxadiazol-2-yl] methoxy}phenyl) acetamide derivatives and to evaluate the hepatocytes regenerator potentiality by molecular docking with 2V2T-NF-KB and as well as In vivo methods and the synthesized compounds were characterized by IR, NMR, and Mass spectroscopy. The in-vivo Hepatoprotective activity was carried out by using albino rats where CCl 4 was used as a hepatotoxin. Molecular docking is performed to find out the binding affinity or molecular interaction energy (kcal/mol) of docked compounds. In silico molecular docking studies displayed the binding energies: -5