7‐Diethylaminocoumarin‐3‐carboxylic acid succinimidyl ester (DEAC SE)

Sabnis, R. W.

doi:10.1002/9781119007104.ch59

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2022

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“…Some commercially available and commonly used for labeling fluorescent coumarins are shown in Figure 1 . Functionalized with carboxylic groups or with activated esters, coumarins ( Figure 1 ) have been aimed for detection of amino acids, small sized proteins, and antibodies through the peptide bond formation [ 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 ]. 7-Diethylamino-coumarin-3-carbohydrazide is used for fluorescence labeling of carbonylated proteins and lipids [ 44 , 45 , 46 , 47 , 48 ].…”

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confidence: 99%

New Azido Coumarins as Potential Agents for Fluorescent Labeling and Their “Click” Chemistry Reactions for the Conjugation with closo-Dodecaborate Anion

et al. 2022

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Novel fluorescent 7-methoxy- and 7-(diethylamino)-coumarins modified with azido-group on the side chain have been synthesized. Their photophysical properties and single crystals structure characteristics have been studied. In order to demonstrate the possibilities of fluorescent labeling, obtained coumarins have been tested with closo-dodecaborate derivative bearing terminal alkynyl group. CuI catalyzed Huisgen 1,3-dipolar cycloaddition reaction has led to fluorescent conjugates formation. The absorption–emission spectra of the formed conjugates have been presented. The antiproliferative activity and uptake of compounds against several human cell lines were evaluated.

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