2015
DOI: 10.3390/molecules200712804
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7-Epiclusianone, a Benzophenone Extracted from Garcinia brasiliensis (Clusiaceae), Induces Cell Cycle Arrest in G1/S Transition in A549 Cells

Abstract: Lung cancer is the leading cause of cancer deaths in the world. Disease stage is the most relevant factor influencing mortality. Unfortunately, most patients are still diagnosed at an advanced stage and their five-year survival rate is only 4%. Thus, it is relevant to identify novel drugs that can improve the treatment options for lung cancer. Natural products have been an important source for the discovery of new compounds with pharmacological potential including antineoplastic agents. We have previously isol… Show more

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Cited by 27 publications
(21 citation statements)
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“…So far, few articles suggested a potential antiproliferative effect of G. brasiliensis after 7- epiclusianone treatment of human cancer cell lines, including melanoma, kidney, ovarian, prostate and lung [ 23 , 24 ].…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…So far, few articles suggested a potential antiproliferative effect of G. brasiliensis after 7- epiclusianone treatment of human cancer cell lines, including melanoma, kidney, ovarian, prostate and lung [ 23 , 24 ].…”
Section: Resultsmentioning
confidence: 99%
“…In A549 lung cells, 7- epiclusianone treatment also induced apoptosis and cell cycle arrest in G1/S transition. Additionally, the cytotoxic activity of 7- epiclusianone in normal fibroblasts (CCD-1059Sk) was also evaluated and IC 50 value was approximately 58 μM, 2.5 and 3.2 times higher than for the cancer cell lines tested herein, U251MG and U138MG [ 24 ].…”
Section: Resultsmentioning
confidence: 99%
“…In this context, natural products have become an important source for the discovery of new therapeutic agents. Plants are especially rich in these types of compounds due to their wide chemical diversity [ 4 ] and represent an important source for new varieties of molecules [ 2 ].…”
Section: Introductionmentioning
confidence: 99%
“…Isogarcinol (2), a natural compound is a new immunosuppressant and has anti-inflammatory effects [22]. 7-epi-clusianone (3) shows antiproliferative activity against cancer cell lines [23] and has influence on proliferation, clonogenic activity cell cycle progression and induction of apoptosis in two glioblastoma cell lines [24]. Clearly, these compounds have considerable clinical potential but they suffer from a lack of sensitive and reliable way to quantify these molecules in the extracts of the Garcinia species.…”
mentioning
confidence: 99%