7 Intention to Treat in Clinical Trials

Fisher, Lloyd D.; Dixon, Dennis O.; Herson, Jay; Frankowski, Ralph F.; Hearron, Martha S.; Peace, Karl E.

doi:10.1201/9780203738610-8

Cited by 111 publications

(107 citation statements)

References 12 publications

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“…The ITT estimation is often regarded in the program evaluation literature as a solution to the imperfect compliance problem [Fisher, Dixon, Herson, Frankowski, Hearron, and Peace (1990)]. ITT analysis strictly depends on the randomized treatment assignment and ignores all sorts of non-compliance in the post-protocol period.…”

Section: Identification Strategymentioning

confidence: 99%

The effects of compulsory military service exemption on education and labor market outcomes: Evidence from a natural experiment

Torun

Tümen

2016

Economics of Education Review

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Based on a law enacted in November 1999, males born on or before December 31st 1972 are given the option to benefit from a paid exemption from the compulsory military service in Turkey. Exploiting this natural experiment, we devise an empirical strategy to estimate the intention-to-treat effect of this paid exemption on the education and labor market outcomes of the individuals in the target group. We find that the paid exemption reform reduces the years of schooling among males who are eligible to benefit from the reform relative to the ineligible ones. In particular, the probability of receiving a college degree or above falls among the eligible males. The result is robust to alternative estimation strategies. We find no reduction in education when we implement the same exercises with (i) data on females and (ii) placebo reform dates. The interpretation is that the reform has reduced the incentives to continue education for the purpose of deferring military service. We also find suggestive evidence that the paid exemption reform reduces the labor income for males in the target group. The reduction in earnings is likely due to the reduction in education.JEL codes: C21, I21, I26, J21, J31.

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Section: Identification Strategymentioning

confidence: 99%

The effects of compulsory military service exemption on education and labor market outcomes: Evidence from a natural experiment

Torun

Tümen

2016

Economics of Education Review

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“…Analysis was performed by the principle of intention to treat (ITT), with analyses conducted according to assignment at randomisation 16,17 . The intention to treat principle allows for modification due to missing data, for which there is no completely satisfactory remedy since strong assumptions are required regardless of the approach taken 18,19 .…”

Section: Discussionmentioning

confidence: 99%

The SSTARS (STeroids and Stents Against Re-Stenosis) Trial: Different stent alloys and the use of peri-procedural oral corticosteroids to prevent in-segment restenosis after percutaneous coronary intervention

Adam

Turley

Mason

et al. 2016

International Journal of Cardiology

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“…ITT has been adopted and mandated by the Food and Drug Administration (FDA) as the preferred approach for analyzing randomized clinical trials (174). The American Statistical Association defined ITT as "one which includes all randomized patients in the groups to which they were randomly assigned, regardless of their compliance with the entry criteria, regardless of the treatment they actually received, and regardless of subsequent withdrawal from treatment or deviation from the protocol" (175).…”

Section: Discussionmentioning

confidence: 99%

Vitamin D plus calcium supplementation among postmenopausal women : effect on risk of heart failure in the Women's Health Initiative.

Donneyong¹

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7 Intention to Treat in Clinical Trials

Cited by 111 publications

References 12 publications

The effects of compulsory military service exemption on education and labor market outcomes: Evidence from a natural experiment

The effects of compulsory military service exemption on education and labor market outcomes: Evidence from a natural experiment

The SSTARS (STeroids and Stents Against Re-Stenosis) Trial: Different stent alloys and the use of peri-procedural oral corticosteroids to prevent in-segment restenosis after percutaneous coronary intervention

Vitamin D plus calcium supplementation among postmenopausal women : effect on risk of heart failure in the Women's Health Initiative.

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