7-Iodo-1H-indole-3-carbonitrile

Abstract

Abstract:The title compound was prepared by a Friedel-Crafts acylation-oxime synthesis-decarboxylation/dehydration sequence starting from commercially available 7-iodoindole with 2-(7-iodo-1H-indol-3-yl)-2-oxoacetic acid as isolated intermediate. The structural identity of the title compound was proven by elemental analysis and spectroscopic methods (IR, NMR, EI-MS), and purity was assessed by two independent HPLC methods.

7-Bromo-1-methyl-2-phenyl-1H-indole-3-carbonitrile

“…In recent years, inhibitors of tumor-related protein kinases were established as major therapeutic options for the treatment of various human cancers [1,2]. In the context of our studies directed to identify new protein kinase inhibitors based on the indole structure [3][4][5][6][7], we were interested in the synthesis of the title compound 7-bromo-1-methyl-2-phenyl-1H-indole 3-carbonitrile (3). (2).…”