7 The use of gonadotrophin-releasing hormone antagonists in polycystic ovarian disease

Lubin, Vanessa; Charbonnel, B.; Bouchard, Philippe

doi:10.1016/s0950-3552(98)80055-2

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Cited by 6 publications

(2 citation statements)

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“…Fertilization and cleavage rates are lower in patients with PCOS undergoing IVF (2). It has been suggested that oocyte maturation is disturbed in patients with PCOS (3, 4).…”

mentioning

confidence: 99%

Follicular fluid levels of anti-Mullerian hormone as a predictor of oocyte maturation, fertilization rate, and embryonic development in patients with polycystic ovary syndrome

Mashiach

Amit

Hasson

et al. 2010

Fertility and Sterility

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“…Fertilization and cleavage rates are lower in patients with PCOS undergoing IVF (2). It has been suggested that oocyte maturation is disturbed in patients with PCOS (3, 4).…”

mentioning

confidence: 99%

Follicular fluid levels of anti-Mullerian hormone as a predictor of oocyte maturation, fertilization rate, and embryonic development in patients with polycystic ovary syndrome

Mashiach

Amit

Hasson

et al. 2010

Fertility and Sterility

View full text Add to dashboard Cite

“…Plazma LH seviyesinin yüksek olduğu durumlarda düşük sayısı da artmaktadır (14). İVF'ye giren PKOS'li hastalarda düşük olan oosit sayısı, fertilizasyon oranı, bölünme oranı, endojen LH salınımı baskılandığında düzeltilebilmektedir.…”

Section: Bulgularunclassified

Efficacy of Gnrh Antagonist Usage in Infertility Patients with Policystic Ovary Syndrome during IUI Cycles

Mayir¹,

Yazici²,

Erkal³

et al. 2017

Turk J Bioch

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GnRH antagonists

Coccia

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Bracco

et al. 2004

European Journal of Obstetrics & Gynecology and Reproductiv

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Ovarian stimulation is an important step in the success rate of in vitro fertilization (IVF) allowing multiple follicular growth, several oocytes and consequently more embryos. The combination of GnRH-antagonists (GnRH-ant) and gonadotrophins is now available for clinical use and represent a valid alternative to classical protocol with GnRH agonist. GnRH-antagonists induce a direct block of GnRH receptor with a rapid decrease in LH and FSH, preventing LH surge. Two protocols has been designed for assisted reproduction technology (ART) treatment: multiple-dose protocol and a single-dose. Both protocols are simply, efficacious, started in the late follicular phase and do not have side effects. A review of GnRH-antagonist applications in ART cycles are presented. Smaller doses of gonadotrophins, shorter stimulation period and lower ovarian hyperstimulation syndrome (OHSS) incidence are reported in literature using GnRH-antagonist compared to agonist. Triggering of ovulation, the use in polycystic ovarian syndrome (PCOS) and poor reponders patients are other interesting indication. Regarding to pregnancy rate and potentially adverse effects of drugs on endometrium or implantation needed more data.

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7 The use of gonadotrophin-releasing hormone antagonists in polycystic ovarian disease

Cited by 6 publications

References 42 publications

Follicular fluid levels of anti-Mullerian hormone as a predictor of oocyte maturation, fertilization rate, and embryonic development in patients with polycystic ovary syndrome

Follicular fluid levels of anti-Mullerian hormone as a predictor of oocyte maturation, fertilization rate, and embryonic development in patients with polycystic ovary syndrome

Efficacy of Gnrh Antagonist Usage in Infertility Patients with Policystic Ovary Syndrome during IUI Cycles

GnRH antagonists

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