713 AGE OF INTRODUCTION OF SOLID FOODS (<2 MONTHS) AND ITS ASSOCIATION WITH ENERGY INTAKE AND ADIPOSITY DURING THE FIRST 3 YEARS OF LIFE

Abstract

and P e d i a t r i c s , Galveston, TX. D i r e c t amelioration of i n t e s t i n a l ischemia using an i n e r t i n t r aluminal oxygen c a r r i e r i s an appealing concept. The perfluorocarbons a r e b i o l o g i c a l l y i n e r t substances known t o r e v e r s i b l y bind oxygen such t h a t passive l o c a l d e l i v e r y of oxygen t o t i s s u e s i s t h e o r e t i c a l l y f e a s i b l e . 75-100 gram weanling male SpragUeDawley r a t s (n=46) were divided i n t o timed study groups from 0.5 t o 5 hours. A l l underwent laparotomy with i d e n t i c a l complete dev a s c u l a r i z a t i o n of two adjacent 5 cm segments of terminal ileum. Each i n t e s t i n a l segment was t r e a t e d with a s i n g l e i n t r a o p e r a t i v e i n s t i l l a t i o n of e i t h e r ;(Transmural 6 superoxygenated FC-43 ( i n i t i a l ~0~5 9 6 ) o r physiologic s a l i n e . Timed s a c r i f i c e was performed and t i s s u e taken f o r l i g h t and --sllne e l e c t r o n microscopy. Blinded a scoring system t o q u a n t i t a t e t h e ischemic i n j u r y . (0= normal t o 6= f u l l thickness n e c r o s i s ) .The fluorocarbon treatment group h a s a s i g n i f i c a n t l y (p<.01) lower h i s t o l o a i c score than t h e s a l i n e t r e a t e d c o n t r o l s a t com--. . -. . ----parable time Goints: i n d i c a t i n g a cytoprotective e f f e c t i n t h e treatment group. (Wilcoxjan s l n r a n k , t e s t ) . The u t i l i t y of t y i s . g r l l i m i n a r g observatlon wiql requxre f u r t h e r laboratory and c I n 1 a experl nce. INTRACTABLE DIARRHEA OF INFANCY (IDI):prospective, 710randomized study of e n t e r a l vs. parenteral therapy. Susan R. Orenstein,% Univ. P i t t . , Pittsburgh, PA.--13 i n f a n t s with I D 1 (age 29-134 days, diarrhea duration 15-49 days, weight below birthweight i n 9/13, and 1 h r serum D-xylose 4.8-13.1 mg/dl) had malabsorption catagorized as "severe" (S, D-xylose (10) o r "moderate" (M, D-xylose >lo). S were randomly assigned t o p a r e n t e r a l (TPN) or continuous nasogastric elemental e n t e r a l (ENT) therapy; M t o ENT or o r a l bolus elemental (ORL) therapy. ENT A l l TPN p a t i e n t s f a i l e d t o normalize D-xylose absorption a f t e r 39 (35-51) days of TPN, so were switched t o ENT. The preceding TPN d i d not shorten t h e i r ENT, nor s i g n i f i c a n t l y speed t h e i r growth, compared with the S ENT group. One S ENT p a t i e n t continued t o l o s e weight a f t e r 1 week of e n t e r a l therapy, so was switched per protocol t o TPN; however, c e n t r a l l i n e s e p s i s 4 days l a t e r forced h i s (successful) return t o ENT. No problems or detectable d i fferences between ENT and ORL occurred i n the M p a t i e n t s . Conclusion:Enteral therapy of I D 1 can produce comparable corr e c t i o n of malnutrition t o TPN, with b e t t e r correction of malabs o r p t i o n , s h o r t e r h o s p i t a l i z a t i o n , and fewer complications.SECRETORY DIARRHEA WITH PROTEIN-LOSING ENTEROP...