An all-fiber mid-infrared enhanced supercontinuum laser source, spanning from ~2 μm to ~4.2 μm, was demonstrated in an erbium-doped ZBLAN fiber amplifier. A 2 μm low repetition rate noise like-pulse mode-locked fiber laser was adopted as the pulse seed for the system. Thanks to using a new-type homemade silica-fluoride fiber pump combiner, the 2.8 μm pulses in the supercontinuum were amplified in the erbium-doped ZBLAN fiber amplifier with all-fiber structure. Due to soliton self-frequency shift, long wavelength components were generated and a 1.4 W mid-infrared enhanced supercontinuum with up to 97% of the power beyond 2.7 μm was obtained in the erbium-doped ZBLAN fiber. This research demonstrated a compact and simple in-amplifier mid-infrared supercontinuum generation with all-fiber structure.