74 year old lady who developed bilateral parkinsonism secondary to an intrinsic cerebral tumour.

Pall, H; Williams, Angela

doi:10.1136/jnnp.50.10.1386

Cited by 8 publications

(3 citation statements)

References 7 publications

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“…Researchers from all cited astrocytoma studies assert in their conclusion that one must perform a neuroradiological exam of patients with parkinsonism to exclude potentially treatable structural causes, such as astrocytomas or other neoplastic lesions (Arcaya Navarro et al., 1986 ; Choi et al., 2012 ; Cicarelli et al., 1999 ; Ho et al., 2008 ; Wächter et al., 2011 ). Other types of glioma reported to cause parkinsonian symptomatology include oligodendroglioma (de Sèze et al., 1998 ), glioblastoma (Ruiz‐Escribano Menchen et al., 2020 ), corpus callosum glioma (Pall & Williams, 1987 ), and low‐grade glioma (Straube & Sigel, 1988 ).…”

Section: Resultsmentioning

confidence: 99%

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Tumoral parkinsonism—Parkinsonism secondary to brain tumors, paraneoplastic syndromes, intracranial malformations, or oncological intervention, and the effect of dopaminergic treatment

et al. 2023

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IntroductionSecondary tumoral parkinsonism is a rare phenomenon that develops as a direct or indirect result of brain neoplasms or related conditions.ObjectivesThe first objective was to explore to what extent brain neoplasms, cavernomas, cysts, paraneoplastic syndromes (PNSs), and oncological treatment methods cause parkinsonism. The second objective was to investigate the effect of dopaminergic therapy on the symptomatology in patients with tumoral parkinsonism.MethodsA systematic literature review was conducted in the databases PubMed and Embase. Search terms like “secondary parkinsonism,” “astrocytoma,” and “cranial irradiation” were used. Articles fulfilling inclusion criteria were included in the review.ResultsOut of 316 identified articles from the defined database search strategies, 56 were included in the detailed review. The studies, which were mostly case reports, provided research concerning tumoral parkinsonism and related conditions. It was found that various types of primary brain tumors, such as astrocytoma and meningioma, and more seldom brain metastases, can cause tumoral parkinsonism. Parkinsonism secondary to PNSs, cavernomas, cysts, as well as oncological treatments was reported. Twenty‐five of the 56 included studies had tried initiating dopaminergic therapy, and of these 44% reported no, 48% low to moderate, and 8% excellent effect on motor symptomatology.ConclusionBrain neoplasms, PNSs, certain intracranial malformations, and oncological treatments can cause parkinsonism. Dopaminergic therapy has relatively benign side effects and may relieve motor and nonmotor symptomatology in patients with tumoral parkinsonism. Dopaminergic therapy, particularly levodopa, should therefore be considered in patients with tumoral parkinsonism.

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Section: Resultsmentioning

confidence: 99%

“…Other types of glioma reported to cause parkinsonian symptomatology include oligodendroglioma (de Sèze et al, 1998), glioblastoma (Ruiz-Escribano Menchen et al, 2020, corpus callosum glioma (Pall & Williams, 1987), and low-grade glioma (Straube & Sigel, 1988).…”

Section: Gliomamentioning

confidence: 99%

Tumoral parkinsonism—Parkinsonism secondary to brain tumors, paraneoplastic syndromes, intracranial malformations, or oncological intervention, and the effect of dopaminergic treatment

et al. 2023

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“…Parkinsonian symptoms due to tumours directly involving the basal ganglia and due to supratentorial tumours sparing the basal ganglia have both been described [1][2][3][4][5]. Bilateral parkinsonism has been less commonly reported than unilateral contralesional parkinsonism [6]. Mechanical compression and distortion of the basal ganglia and nigrostriatal pathway, tumour infiltration and impaired tissue perfusion due to tumour oedema have been proposed as causative mechanisms [1,7].…”

Section: Discussionmentioning

confidence: 99%

Meningioma presenting as bilateral parkinsonism

Adhiyaman

Meara

2003

Age and Ageing

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cerebral tumour is an uncommon cause of parkinsonism. Symptoms probably occur due to compression and distortion of the basal ganglia and nigrostriatal pathway. Diagnosis of the underlying pathology can be delayed by this presentation. Since complete recovery is possible parkinsonian patients with atypical symptoms, poor response to dopaminergic drugs, and focal neurological signs should undergo neuroimaging.

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