740 Placebo-controlled trial of vitamin K supplementation on bone mineral density in primary biliary cirrhosis(PBC)

Gleeson, D.; Hodges, Stephen; Rigney, Elizabeth; Blumsohn, Aubrey; Hannon, R. R.; Peel, Nicola; Eastell, Richard

doi:10.1016/s0270-9139(03)80782-6

Cited by 6 publications

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“…In contrast, some studies demonstrated that VK cannot be used in patients with liver disease [ 85 , 86 , 87 , 88 , 89 ]. A retrospective study of patients with cirrhosis reported that VK was not useful for cirrhosis, but could be supplemented parenterally only during cholestasis [ 85 ].…”

Section: Vitamin K Supplementation In Cholestasis and Other Hepatic Diseasesmentioning

confidence: 99%

“…A retrospective study of patients with cirrhosis reported that VK was not useful for cirrhosis, but could be supplemented parenterally only during cholestasis [ 85 ]. In a placebo-controlled trial of VK supplementation on BMD in PBC, one group of patients was treated with 2 mg/day of VK orally for one year [ 86 ]. All patients received oral calcium at 1 g/day and VD at 20 μg/day for one month prior to randomization and continued throughout the study.…”

Section: Vitamin K Supplementation In Cholestasis and Other Hepatic Diseasesmentioning

confidence: 99%

“…All patients received oral calcium at 1 g/day and VD at 20 μg/day for one month prior to randomization and continued throughout the study. No significant effect of VK treatment was found in BMD of the spine (L2–L4) or femoral neck [ 86 ]. Saja et al found that VK was not able to significantly improve the majority of coagulation parameters in patients with liver disease [ 87 ].…”

Section: Vitamin K Supplementation In Cholestasis and Other Hepatic Diseasesmentioning

confidence: 99%

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The Role of Vitamin K in Cholestatic Liver Disease

2021

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Vitamin K (VK) is a ligand of the pregnane X receptor (PXR), which plays a critical role in the detoxification of xenobiotics and metabolism of bile acids. VK1 may reduce the risk of death in patients with chronic liver failure. VK deficiency is associated with intrahepatic cholestasis, and is already being used as a drug for cholestasis-induced liver fibrosis in China. In Japan, to treat osteoporosis in patients with primary biliary cholangitis, VK2 formulations are prescribed, along with vitamin D3. Animal studies have revealed that after bile duct ligation-induced cholestasis, PXR knockout mice manifested more hepatic damage than wild-type mice. Ligand-mediated activation of PXR improves biochemical parameters. Rifampicin is a well-known human PXR ligand that has been used to treat intractable pruritus in severe cholestasis. In addition to its anti-cholestatic properties, PXR has anti-fibrotic and anti-inflammatory effects. However, because of the scarcity of animal studies, the mechanism of the effect of VK on cholestasis-related liver disease has not yet been revealed. Moreover, the application of VK in cholestasis-related diseases is controversial. Considering this background, the present review focuses on the effect of VK in cholestasis-related diseases, emphasizing its function as a modulator of PXR.

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Section: Vitamin K Supplementation In Cholestasis and Other Hepatic Diseasesmentioning

confidence: 99%

Section: Vitamin K Supplementation In Cholestasis and Other Hepatic Diseasesmentioning

confidence: 99%

Section: Vitamin K Supplementation In Cholestasis and Other Hepatic Diseasesmentioning

confidence: 99%

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The Role of Vitamin K in Cholestatic Liver Disease

2021

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The Semantic Sphere 1

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There are many shades and intensities of space, beginning with the most obvious: how we know where we are, transiting to how we experience space as a sensory realm: how we feel where we are. The where and the how are being transformed as we move into a period in which our infrastructures are being inscribed on the planet as a new era, known as the Anthropocene. Space is stabilized and parceled out as though it were ours to own by the forces of the state and the economy.

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740 Placebo-controlled trial of vitamin K supplementation on bone mineral density in primary biliary cirrhosis(PBC)

Cited by 6 publications

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The Role of Vitamin K in Cholestatic Liver Disease

The Role of Vitamin K in Cholestatic Liver Disease

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