752 Loss of periplakin expression is associated with pathological stage and cancer-specific survival in patients with urothelial carcinoma of the urinary bladder

Matsumoto, Keiji; Hirayama, Takehisa; Ikeda, Masaomi; Nishi, Morihiro; Fujita, T; Irie, Akira; Yoshida, Kazunari; Sato, Yoshikazu; Iwamura, M.

doi:10.1016/s1569-9056(15)60743-6

Cited by 2 publications

(2 citation statements)

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“…The role of periplakin on IHs remains an open question. Of note, the loss of periplakin has been associated with the pathological stage of urothelial carcinoma of the urinary bladder 102 . We confirmed that the relative expression of PPL was much higher for IHs in the involution phase (see Fig.…”

Section: Pplmentioning

confidence: 99%

Identification of putative biomarkers for Infantile Hemangiomas and Propranolol treatment via data integration

Gómez-Acevedo

Dai²,

Strub

et al. 2020

Sci Rep

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Infantile hemangiomas (IHs) are the most common benign tumors in early childhood. They show a distinctive mechanism of tumor growth in which a rapid proliferative phase is followed by a regression phase (involution). Propranolol is an approved treatment for IHs, but its mechanism of action remains unclear. We integrated and harmonized microRNA and mRNA transcriptome data from newly generated microarray data on IHs with publicly available data on toxicological transcriptomics from propranolol exposure, and with microRNA data from IHs and propranolol exposure. We identified subsets of putative biomarkers for proliferation and involution as well as a small set of putative biomarkers for propranolol's mechanism of action for IHs, namely EPAS1, LASP1, SLC25A23, MYO1B, and ALDH1A1. Based on our integrative data approach and confirmatory experiments, we concluded that hypoxia in IHs is regulated by EPAS1 (HIF-2α) instead of HIF-1α, and also that propranolol-induced apoptosis in endothelial cells may occur via mitochondrial stress. Infantile hemangiomas (IHs) are the most common benign tumor of the vascular endothelium in infants and are present in 4 to 10% of children younger than 12 months 1,2. They manifest in any part of the body but around 60% of the cases arise in the head and neck 3. IHs have a unique growth pattern that is divided into three phases: proliferation, quiescence and involution 4. Despite the fact that the majority of IHs involute completely by 7 years of age, their hyper-proliferation can cause significant functional and disfiguring consequences and morbidities such as ulceration, bleeding, and pain. It is estimated that up to 40% of the lesions will require either surgical or medical intervention 3,5. Histologically, IHs in the proliferative phase show a lack of organization of blood vessels with densely packed capillaries composed of immature endothelial cells surrounded by pericytes, whereas during involution the capillaries are replaced with fatty and fibrous tissue 6. These findings suggest that the proliferation phase is orchestrated by angiogenesis or growth factors that lead to high mitotic rates. Among such markers reported in the literature are vascular endothelial growth factor A (VEGF-A) 7 , basic fibroblast growth factor (bFGF), proliferating cell nuclear antigen (PCNA), type IV collagenase 8 , and insulin-like growth factor 2 (IGF-2) 9. On the other hand, during the involution phase there is a high expression of antiangiogenic factors (e.g., tissue inhibitor of metalloproteinase TIMP1) 8 and increasing apoptosis of endothelial cells 10. However, high expression of growth factors in both the proliferating and involution phases (e.g. bFGF) makes it difficult to clearly identify causative factors for IHs' development. From the clinical perspective, it is important to find biomarkers that robustly differentiate between proliferation and involution phases on IHs, with the hope that those biomarkers will guide medical decisions towards optimal treatments. Propranolol is a non-selective β-adre...

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Section: Pplmentioning

confidence: 99%

Identification of putative biomarkers for Infantile Hemangiomas and Propranolol treatment via data integration

Gómez-Acevedo

Dai²,

Strub

et al. 2020

Sci Rep

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“…There were no researches about the roles of FUT7, PADI1, PPL, and ARHGAP40 in LSCC, but the roles of these genes or the related genes in other cancers were reported. For example, lower expression of PPL is related to cancer-specific survival and pathological stage in urothelial carcinoma of the urinary bladder [ 39 ]. Cui et al [ 40 ] demonstrated that overexpression of exogenous FUT7 contributed to migration and adhesion of cell line MDAMB-231 of breast cancer.…”

Section: Discussionmentioning

confidence: 99%

Potential prognostic markers and significant lncRNA–mRNA co-expression pairs in laryngeal squamous cell carcinoma

Wang

Liu

et al. 2021

Open Life Sciences

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lncRNA–mRNA co-expression pairs and prognostic markers related to the development of laryngeal squamous cell carcinoma (LSCC) were investigated. The lncRNA and mRNA expression data of LSCC in GSE84957 and RNA-seq data of 112 LSCC samples from TCGA database were used. Differentially expressed genes (DEGs) and lncRNAs (DE-lncRNAs) between LSCC and para-cancer tissues were identified. Co-expression analysis of DEGs and DE-lncRNA was conducted. Protein–protein interaction network for co-expressed DEGs of top 25 DE-lncRNA was constructed, followed by survival analysis for key nodes in co-expression network. Finally, expressions of several DE-lncRNAs and DEGs were verified using qRT-PCR. The lncRNA–mRNA network showed that ANKRD20A5P, C21orf15, CYP4F35P, LOC_I2_011146, XLOC_006053, XLOC_I2_003881, and LOC100506027 were highlighted in network. Some DEGs, including FUT7, PADI1, PPL, ARHGAP40, MUC21, and CEACAM1, were co-expressed with above lncRNAs. Survival analysis showed that PLOD1, GLT25D1, and KIF22 were significantly associated with prognosis. qRT-PCR results showed that the expressions of MUC21, CEACAM1, FUT7, PADI1, PPL, ARHGAP40, ANKRD20A5P, C21orf15, CYP4F35P, XLOC_I2_003881, LOC_I2_011146, and XLOC_006053 were downregulated, whereas the expression of LOC100506027 was upregulated in LSCC tissues. PLOD1, GLT25D1, and KIF22 may be potential prognostic markers in the development of LSCC. C21orf15-MUC21/CEACAM1/FUT7/PADI1/PPL/ARHGAP40 are potential lncRNA–mRNA pairs that play significant roles in the development of LSCC.

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752 Loss of periplakin expression is associated with pathological stage and cancer-specific survival in patients with urothelial carcinoma of the urinary bladder

Cited by 2 publications

References 0 publications

Identification of putative biomarkers for Infantile Hemangiomas and Propranolol treatment via data integration

Identification of putative biomarkers for Infantile Hemangiomas and Propranolol treatment via data integration

Potential prognostic markers and significant lncRNA–mRNA co-expression pairs in laryngeal squamous cell carcinoma

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