766: A Curious Case of Pembrolizumab-Induced Myasthenia Gravis

Petro, Joseph; Burak, N.; Bogart, Michael; Markley, Daniel

doi:10.1097/01.ccm.0000728952.35890.5a

Critical Care Medicine

2020

DOI: 10.1097/01.ccm.0000728952.35890.5a

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766: A Curious Case of Pembrolizumab-Induced Myasthenia Gravis

Joseph Petro¹,

N. Burak

Michael Bogart

et al.

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Myasthenia gravis: case reportA 68-year-old woman developed myasthenia gravis (MG) during treatment with pembrolizumab for triple-negative breast cancer. The woman, who had triple-negative breast cancer, started receiving unspecified chemotherapy and pembrolizumab [route and dosage not stated]. She presented to hospital after being found down at home. Initially, she was treated for sepsis with respiratory compromise due to methicillin-susceptible Staphylococcus aureus pneumonia. However, her treatment course was complicated by thrombocytopenia, acute kidney injury and reintubation due to weakness. A neurology consultation was sought in the setting of pembrolizumab-induced myasthenia gravis [duration of treatment to reaction onset not stated].The woman was treated with unspecified steroids, immune-globulin [IVIG], mestinon and plasmapheresis with rapid improvement. Subsequently, she was extubated and physical therapy was started. Eventually, she was discharged to rehab.

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766: A Curious Case of Pembrolizumab-Induced Myasthenia Gravis

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