78. Cytokine-induced depression: Effects of interleukin-1 beta and corticotropin-releasing factor antagonism on biochemical and behavioral indicators of “depression” in the rat

Loftis, Jennifer M.; Murphy-Crews, A.; Menasco, Daniel; Huckans, Marilyn; Strater, Max

doi:10.1016/j.bbi.2009.06.083

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“…Manipulating the signaling functions of cytokines and their receptors by altering downstream effector molecules may also provide information about relevant inflammatory pathways involved in depression. Recently, we reported that treatment with IL-1β increased the phosphorylation of p38 MAP kinase in rat frontal cortex (Loftis et al, 2009a,b), a kinase that activates specific intracellular signaling pathways and transcription factors leading to the increased production of proinflammatory modulators. Thus, use of a conditional p38 MAP kinase knockout mouse model may also be useful in testing novel therapeutic strategies for depression (Kim et al, 2008).…”

Section: Animal Models and Hypothesized Mechanisms Of Cytokine-inducementioning

confidence: 99%

Neuroimmune mechanisms of cytokine-induced depression: Current theories and novel treatment strategies

Loftis

Huckans

Morasco

2010

Neurobiology of Disease

219

150

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The relationships between immune and neural function are an increasingly important area of study for neuropsychiatric disorders, in particular depression. This is exemplified by the growing number of publications on cytokines and depression during the last 10 years, as compared to earlier decades. This review summarizes the current theories and novel treatment strategies for depression, with a focus on cytokine-induced depression. Neuroimmune mechanisms are now viewed as central to the development of depressive symptoms and emerging evidence is beginning to identify the neural circuits involved in cytokine-induced depression. The current diagnostic categories for depression, as defined by the Diagnostic and Statistical Manual of Mental Disorders, however, are not etiologically or biologically derived, and it has been proposed that "depression", likely reflects multiple pathogeneses leading to varying symptom constellations. As we move toward a better biological understanding of depression-related symptom constellations or syndromes, the term "depression" may prove inadequately broad, and an integration of interdisciplinary literatures will increase in importance. Future research should aim to characterize these depression-related symptom constellations or syndromes better with the goal of optimizing treatment strategies.

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Section: Animal Models and Hypothesized Mechanisms Of Cytokine-inducementioning

confidence: 99%

Neuroimmune mechanisms of cytokine-induced depression: Current theories and novel treatment strategies

Loftis

Huckans

Morasco

2010

Neurobiology of Disease

219

150

View full text Add to dashboard Cite

show abstract

78. Cytokine-induced depression: Effects of interleukin-1 beta and corticotropin-releasing factor antagonism on biochemical and behavioral indicators of “depression” in the rat

Cited by 1 publication

References 0 publications

Neuroimmune mechanisms of cytokine-induced depression: Current theories and novel treatment strategies

Neuroimmune mechanisms of cytokine-induced depression: Current theories and novel treatment strategies

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