780: Antibiotic Prophylaxis in Postoperative Neurosurgical Patients With a Drain: Brief Versus Extended

Smith, K; Bergeron, Erica; Hire, Ryan; Chandler, Elisabeth; Rosado-Odom, Vera

doi:10.1097/01.ccm.0000809444.94667.19

Cited by 2 publications

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“…Further prospective studies exploring the duration of ventricular opening, foreign body placement, and utility of CSF surveillance would be bene cial. Of note, current neurocritical care guidelines suggest no more than a single dose of prophylactic antibiotics at the time of drain or shunt insertion, as well as limiting postoperative antibiotic duration to < 24 hours [7,9].…”

Section: Discussionmentioning

confidence: 99%

Additive risk of surgical site infection from more than one risk factor following craniotomy for tumor

et al. 2023

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This study seeks to expound upon risk factor etiologies for surgical site infection (SSI) and investigate their combinatorial effects on infection rate following craniotomy for neuro-oncologic pathology. MethodsPatients who underwent neuro-oncologic craniotomy between 2006-2020 were included. Medical records were reviewed to identify the occurrence of wound infection at ≤3 months postoperatively. Potential risk factors for infection included tumor pathology, location, anesthesia type, indication, ventricular entry, foreign body, brachytherapy, lumbar drain, prior operation, prior cranial radiation, prior infection, bevacizumab, and medical comorbidities (hypertension, obesity, hyperlipidemia, other cancer, cirrhosis).Logistic regression was implemented to determine risk factors for SSI. Chi-square tests were used to assess whether the number of risk factors (e.g., 0, ≥1, ≥2, ≥3, ≥4) increases the risk of SSI compared to patients with fewer risk factors. The relative increase with each additional risk factor was also evaluated. ResultsA total of 1209 patients were included. SSI occurred in 42 patients (3.5%) by 90 days after surgery.Signi cant risk factors on binary logistic regression were bevacizumab (OR 40.84; p<0.001), cirrhosis (OR 14.20, p=0.03), foreign body placement (OR 4.06; P<0.0001), prior radiation (OR 2.20; p=0.03), and prior operation (OR 1.92; p=0.04). Infection rates in the combinatorial analysis were as follows: ≥1 risk factor = 5.9% (OR 2.74; p=0.001), ≥2 = 6.7% (OR 2.28; p=0.

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Section: Discussionmentioning

confidence: 99%

Additive risk of surgical site infection from more than one risk factor following craniotomy for tumor

et al. 2023

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Additive Risk of Surgical Site Infection from More than One Risk Factor Following Craniotomy for Tumor

Maayan

Lavieri

Babu

et al. 2023

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Purpose This study seeks to expound upon risk factor etiologies for surgical site infection (SSI) and investigate their combinatorial effects on infection rate following craniotomy for neuro-oncologic pathology. Methods Patients who underwent neuro-oncologic craniotomy between 2006-2020 were included. Medical records were reviewed to identify the occurrence of wound infection at ≤3 months postoperatively. Potential risk factors for infection included tumor pathology, location, anesthesia type, indication, ventricular entry, foreign body, brachytherapy, lumbar drain, prior operation, prior cranial radiation, prior infection, bevacizumab, and medical comorbidities (hypertension, obesity, hyperlipidemia, other cancer, cirrhosis). Logistic regression was implemented to determine risk factors for SSI. Chi-square tests were used to assess whether the number of risk factors (e.g., 0, ≥1, ≥2, ≥3, ≥4) increases the risk of SSI compared to patients with fewer risk factors. The relative increase with each additional risk factor was also evaluated. Results A total of 1209 patients were included. SSI occurred in 42 patients (3.5%) by 90 days after surgery. Significant risk factors on binary logistic regression were bevacizumab (OR 40.84; p<0.001), cirrhosis (OR 14.20, p=0.03), foreign body placement (OR 4.06; P<0.0001), prior radiation (OR 2.20; p=0.03), and prior operation (OR 1.92; p=0.04). Infection rates in the combinatorial analysis were as follows: ≥1 risk factor = 5.9% (OR 2.74; p=0.001), ≥2 = 6.7% (OR 2.28; p=0.01), ≥3 = 19.0% (OR 6.5; p<0.0001), ≥4 = 100% (OR 30.2; p<0.0001). Conclusions Risk factors in aggregate incrementally increase the risk of postoperative SSI after craniotomy for tumor.

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780: Antibiotic Prophylaxis in Postoperative Neurosurgical Patients With a Drain: Brief Versus Extended

Cited by 2 publications

References 0 publications

Additive risk of surgical site infection from more than one risk factor following craniotomy for tumor

Additive risk of surgical site infection from more than one risk factor following craniotomy for tumor

Additive Risk of Surgical Site Infection from More than One Risk Factor Following Craniotomy for Tumor

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