786-P: Serum Dehydroepiandrosterone Sulfate Concentration and Animal Protein Intakes Are Important Factors for Skeletal Muscle Mass in Japanese Patients with Type 2 Diabetes

Abstract

The aim of this study was to examine the association between serum reproductive hormone concentrations, dietary intakes and skeletal muscle mass in patients with type 2 diabetes. This cross-sectional study investigated 54 Japanese patients with type 2 diabetes (32 males) during the period between 2014 to 2018. All patients completed measurements of serum dehydroepiandrosterone sulfate concentration (DHEA-S), skeletal muscle index (SMI) and dietary intakes at same period. Those who had adrenal tumor, thyroid cancer, and thyroid dysfunction were excluded. In the analysis, as a first-step, we conducted single regression analysis between age, DHEA-S, SMI, total energy and each macronutrient intakes. SMI was positively correlated with total energy and protein intakes. Interestingly, while protein intakes derived from animal foods were positively correlated with SMI, those from plant foods showed negative correlation. On the other hand, DHEA-S was positively correlated with SMI. Then, multiple regression analysis (MRS) was performed to examine the contributors to SMI (Table). MRS revealed the association of SMI with DHEA-S and protein intakes. Our data suggest that DHEA-S and protein intakes are the factors contribute to SMI in Japanese patients with type 2 diabetes. Disclosure S. Moyama: None. H. Kuwata: Research Support; Self; Eli Lilly and Company. Y. Hamamoto: Speaker's Bureau; Self; Novo Nordisk A/S. D. Yabe: Advisory Panel; Self; Abbott. Research Support; Self; Astellas Pharma Inc. Speaker's Bureau; Self; AstraZeneca, Boehringer Ingelheim Pharmaceuticals, Inc., Daiichi Sankyo Company, Limited, Eli Lilly and Company, Merck Sharp & Dohme Corp., Novo Nordisk Inc., Ono Pharmaceutical Co., Ltd., Sanofi K.K., Taisho Pharmaceutical Co., Ltd., Takeda Pharmaceutical Company Limited. Y. Seino: Research Support; Self; Arkray, Inc., Boehringer Ingelheim Pharmaceuticals, Inc., Eli Lilly and Company, Merck & Co., Inc., Novo Nordisk Inc., Ono Pharmaceutical Co., Ltd., Taisho Pharmaceutical Co., Ltd., Takeda Pharmaceutical Company Limited, Terumo Medical Corporation.