7A-4 A New Method for Enhancing Dynamic Vascular Patterns of Focal Liver Lesions in Contrast Ultrasound

Quantitative analysis of contrast-enhanced ultrasonography: differentiating focal nodular hyperplasia from hepatocellular carcinoma

“…The software permitted the quantification of contrast Quantitative analysis of CEUS: differentiating FNH from HCC enhancement from a time sequence of perfusion frames and provided a modified lognormal distribution for bestfit optimisation, which was based on the indicator dilution theory after an intravenous bolus of contrast agents [12]. The region of interest (ROI) in the lesion was defined in the interior corresponding to .20% of the whole lesion, avoiding central large vessels, necroses and the edge of the lesion.…”

Quantitative evaluation of viable tissue perfusion changes with contrast-enhanced greyscale ultrasound in a mouse hepatoma model following treatment with different doses of thalidomide

“…In each ROI, the mean video intensity induced by contrast uptake was calculated for each image and was expressed in arbitrary units. The timeintensity curve for each imaging protocol was plotted and a mathematical equation model was used to fit the contrast uptake time-intensity curve [10]. The perfusion parameters calculated from the fitted model were area under the curve (AUC), maximum intensity (IMAX), perfusion index (PI), mean transit time (MTT), time to peak (TTP) and quality of fit (QOF).…”

Contrast-enhanced ultrasonography of cervical carcinoma: perfusion pattern and relationship with tumour angiogenesis

“…A modified log-normal distribution was used for bestfit optimization. 30 Perfusion variables calculated from the fitted model included: maximum intensity (IMAX), defined as the maximum increase in signal intensity produced by injection of the contrast agent and calculated as the ratio of the peak intensity of the analysis ROI and the reference ROI (100%); rise time (RT), defined as the interval during which the intensity reached 10-90% of IMAX; time to peak (TTP), defined as the interval from the beginning of enhancement to the peak of the fitted curve; and the quality of fit, which was used to test the fit between the raw data and the fitted mathematic model (Figure 2). 16,20 Pathology analysis Pathology was performed in all 60 patients.…”