7T MRI and molecular studies of Dotarem (gadoterate meglumine) retention in macrophages.

Uosef, Ahmed; Subuddhi, Arijita; Lu, Annie; Ubelaker, Henry V.; Karmonik, Christof; Wosik, J.; Ghobrial, Rafik M.; Kloc, Małgorzata

doi:10.1016/j.jmro.2022.100085

Cited by 2 publications

(1 citation statement)

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“…Other plausible mechanisms underlying Gd (III) toxicity include blockage of adenosine diphosphate and adenosine triphosphate (ATP) hydrolysis through stimulation of angiotensin II AT1 receptors [78]; inhibition of ATP-permeable channels [106]; interference with the epithelial Na + -channel's activity [63]; downregulation of RhoA, mTORC1, and mTORC2 proteins [31]; and inhibition on both inward and outward ionic current through Gd (III) accumulation at the binding site of the Na + -Ca 2+ exchanger protein that carries the current [104]. It may also interfere with the mobilization of iron [29,67], as it has been associated with total iron-binding capacity (TIBC) decrease [75], and to increases in serum iron, ferritin [41,75,80], and transferrin saturation [75].…”

Section: Reference Study Design Main Findingsmentioning

confidence: 99%

Toxicity Mechanisms of Gadolinium and Gadolinium-Based Contrast Agents—A Review

Coimbra,

Rocha,

Sousa

et al. 2024

IJMS

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Gadolinium-based contrast agents (GBCAs) have been used for more than 30 years to improve magnetic resonance imaging, a crucial tool for medical diagnosis and treatment monitoring across multiple clinical settings. Studies have shown that exposure to GBCAs is associated with gadolinium release and tissue deposition that may cause short- and long-term toxicity in several organs, including the kidney, the main excretion organ of most GBCAs. Considering the increasing prevalence of chronic kidney disease worldwide and that most of the complications following GBCA exposure are associated with renal dysfunction, the mechanisms underlying GBCA toxicity, especially renal toxicity, are particularly important. A better understanding of the gadolinium mechanisms of toxicity may contribute to clarify the safety and/or potential risks associated with the use of GBCAs. In this work, a review of the recent literature concerning gadolinium and GBCA mechanisms of toxicity was performed.

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