7α,15-Dihydroxydehydroabietic acid from Pinus koraiensis inhibits the promotion of angiogenesis through downregulation of VEGF, p-Akt and p-ERK in HUVECs

Lee, Tae Kyoung; Park, Jun Yeon; Yu, Jae Sik; Jang, Tae Su; Oh, Seong Taek; Pang, Changhyun; Ko, Yoon‐Joo; Kang, Ki Sung; Kim, Ki Hyun

doi:10.1016/j.bmcl.2018.02.014

Cited by 16 publications

(6 citation statements)

References 34 publications

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“…Up to date, RA-derived compounds with different pharmacological effects—anti-inflammatory [77], antimicrobial [12,78], fungicidal [12,22,23,79], anxiolytic [80], antiviral [23], antitumor [23,43,81], and anti-angiogenic [82]—have been described. In addition, RA derivatives can be used as intermediates in the synthesis of bioactive compounds [13,83] and pharmaceuticals [84,85].…”

Section: Biotransformation Of Ras To Bioactive Compoundsmentioning

confidence: 99%

Microbial Conversion of Toxic Resin Acids

et al. 2019

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Organic wood extractives—resin acids—significantly contribute to an increase in the toxicity level of pulp and paper industry effluents. Entering open ecosystems, resin acids accumulate and have toxic effects on living organisms, which can lead to the ecological imbalance. Among the most effective methods applied to neutralize these ecotoxicants is enzymatic detoxification using microorganisms. A fundamental interest in the in-depth study of the oxidation mechanisms of resin acids and the search for their key biodegraders is increasing every year. Compounds from this group receive attention because of the need to develop highly effective procedures of resin acid removal from pulp and paper effluents and also the possibility to obtain their derivatives with pronounced pharmacological effects. Over the past fifteen years, this is the first report analyzing the data on distribution, the impacts on living organisms, and the microbial transformation of resin acids. Using the example of dehydroabietic acid—the dominant compound of resin acids in effluents—the review discusses the features of interactions between microorganisms and this pollutant and also highlights the pathways and main products of resin acid bioconversion.

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Section: Biotransformation Of Ras To Bioactive Compoundsmentioning

confidence: 99%

Microbial Conversion of Toxic Resin Acids

et al. 2019

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“…Currently, several P. koraiensis research programs are primarily concerned with the study of chemical components of pine nuts (Kim et al 2012;Shpatov et al 2017;Lee et al 2018), the identification of molecular markers (Kim et al 2005;Chen et al 2011), asexual reproduction techniques (Liu 2004;Song et al 2007), the establishment of seed orchards (Oh et al 2008;Feng et al 2010) and eco-physiological attributes (Makoto and Koike 2007;Sun et al 2016). There has been limited conventional breeding research on P. koraiensis although the evaluation of progenies from seed orchards can serve as materials for the selection of elite families and single plants.…”

Section: Introductionmentioning

confidence: 99%

Variations in growth traits and wood physicochemical properties among Pinus koraiensis families in Northeast China

Zhang

Pei

et al. 2022

J. For. Res.

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This study aimed to explore and improve the different economic values of Pinus koraiensis (Siebold and Zucc.) by examining the variations in 6 growth traits and 9 physicochemical wood properties among 53 P. koraiensis half-sib families. Growth traits assessed included height, diameter at breast height, volume, degree of stem straightness, stem form, and branch number per node, while wood properties assessed included density, fiber length and width, fiber length to width ratio, and cellulose, hemicellulose, holocellulose, lignin, and ash contents. Except for degree of stem straightness and branch number per node, all other traits exhibited highly significant variations (P < 0.01) among families. The coefficients of variation ranged from 5.3 (stem form) to 66.7% (ash content), whereas, the heritability ranged from 0.136 (degree of stem straightness) to 0.962 (ash content). Significant correlations were observed among growth traits and wood physicochemical properties. Principal component analysis identified four distinct groups representing growth traits, wood chemical and physical properties, and stem form traits. Multi-trait comprehensive evaluation identified three groups of elite families based on breeding objectives, including rapid growth, improved timber production for building and furniture materials, and pulpwood production. These specific families should be used to establish new plantations.

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“…Pinecone is an important organ of Pinus koraiensis , with the effects of antitussive, expectorant and anti-inflammatory, and it is rich in essential oil. In addition, Pinus koraiensis pinecones extracts had a variety of physiological activities such as anti-tumor, anti-angiogenesis, and anti-radiation [16,17,18]. According to reports, pine needle essential oils (from four Pinus genera: p. mugo subsp.…”

Section: Introductionmentioning

confidence: 99%

Essential Oil from Pinus Koraiensis Pinecones Inhibits Gastric Cancer Cells via the HIPPO/YAP Signaling Pathway

et al. 2019

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Pinecone is a traditional folk herb, which has been used in China for many years. In this paper, the essential oil from Pinus koraiensis pinecones (PEO) was obtained by hydrodistillation and 41 compounds were identified by gas chromatography–mass spectrometry (GC-MS), mainly including α-Pinene (40.91%), Limonene (24.82%), and β-Pinene (7.04%). The purpose of this study was to investigate the anti-tumor activity of PEO on MGC-803 cells and its mechanism. Anti-tumor experiments in vitro showed PEO could significantly inhibit the proliferation and migration of MGC-803 cells, and it also could arrest the cell cycle in the G2/M phase, decrease the mitochondrial membrane potential, and induce apoptosis. Finally, the effects of PEO on genes expression on MGC-803 cells were analyzed by RNA sequencing, and results showed that after treatment with PEO, 100 genes were up-regulated, and 57 genes were down-regulated. According to the KEGG pathway and GSEA, FAT4, STK3, LATS2, YAP1, and AJUBA were down-regulated, which were related to HIPPO signaling pathway. Real-time PCR and western blot further confirmed the results of RNA sequencing. These results indicated that PEO may exert anti-tumor activity via the HIPPO/YAP signaling pathway. The anti-tumor mechanism of this oil can be further studied, which is important for the development of anti-tumor drugs.

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7α,15-Dihydroxydehydroabietic acid from Pinus koraiensis inhibits the promotion of angiogenesis through downregulation of VEGF, p-Akt and p-ERK in HUVECs

Cited by 16 publications

References 34 publications

Microbial Conversion of Toxic Resin Acids

Microbial Conversion of Toxic Resin Acids

Variations in growth traits and wood physicochemical properties among Pinus koraiensis families in Northeast China

Essential Oil from Pinus Koraiensis Pinecones Inhibits Gastric Cancer Cells via the HIPPO/YAP Signaling Pathway

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