8-Hydroxyquinoline-5-Sulfonic Acid-Containing Poly(Vinyl Alcohol)/Chitosan Electrospun Materials and Their Cu2+ and Fe3+ Complexes: Preparation, Antibacterial, Antifungal and Antitumor Activities

Abstract

Novel poly(vinyl alcohol) (PVA)/chitosan (Ch)-based fibrous materials containing an ionizable model drug, 8-hydroxyquinoline-5-sulfonic acid (SQ), were successfully fabricated by electrospinning. Complexes between the components of the crosslinked PVA/Ch/SQ mats and Cu2+ and Fe3+ ions were formed. The coordination of these ions in the mats was examined by electron paramagnetic resonance spectroscopy (EPR). The microbiological screening against S. aureus and C. albicans revealed that both the incorporation of SQ in the mats and the complexation with Cu2+ and Fe3+ imparted to these materials antibacterial and antifungal activities. Moreover, the SQ-containing mats and their complexes displayed good cytotoxicity against human cervical HeLa tumor cells. The most prominent was the cytotoxicity of the Cu2+ complex of the mats. The combined antibacterial, antifungal and in vitro antitumor activities render these novel materials promising candidates for wound dressing applications and for application in the local treatment of cervical tumors.

Application of Electrospun Drug-Loaded Nanofibers in Cancer Therapy

“…As previously highlighted, electrospun drug-loaded nanofibers offer high drug loading, exceptional encapsulation efficiency, and specific drug release profiles, including sustained, multiphase, targeted, and combined release. These capabilities are achieved through meticulous material selection and design, presenting specific and extensive applications in cancer treatment [ 113 , 114 , 115 ]. This section delineates their applications across various tumor therapies.…”

Synthesis and Characterization of Slow-Release Chitosan Oligosaccharide Pyridine Schiff Base Copper Complexes with Antifungal Activity

“…Chitosan [β-(1–4)-2-amino-2-deoxy- d -glucan], a cationic polymer derived from the deacetylation of chitin found in shrimp and crab shells, , exhibits potent antimicrobial, antioxidant, and antitumor properties and holds great potential for applications in biogenic pesticides, functional foods, and biomaterials. − However, its large molecular weight creates limitations because it can only be dissolved at acidic pH, thereby creating challenges for its use . To overcome these limitations, researchers have synthesized chitosan oligosaccharide (COS) via chemical or enzymatic hydrolysis .…”

Antibacterial Activity of Carboxymethyl Chitosan Dialdehyde Starch Schiff Base and its Metal Complex

“…In addition, the metal ions could easily combine with oxygen in organisms, and then denatured proteins or enzymes [16,17] through effect on the synthesis of amino acids, proteins, lipoproteins and coenzymes according with the formation of stable complexes. The antibacterial activity of chitosan Schiff base metal complexes [Cu(II) [18,19], Ag (II) [20,21], Zn(II) [22]] against E. coli, S. aureus, salmonella and B. subtilis was signi cantly higher than that of free ligand, and increased with the increase of the minimum concentration [23,24]. A novel water-soluble isoniazid grafted O-carboxymethyl chitosan Schiff base [25] was synthesized by chitosan, 1,3-diphenyl-1, 3-propanedione and mono chloroacetic acid, and then its metal complexes [Co(II), Cu(II), Zn(II)] was obtained, moreover, the results of antibacterial activity tests showed that the metal complexes exhibited better inhibitory effect on P. aeruginosa and S. aureus.…”

“…In addition, the metal ions could easily combine with oxygen in organisms, and then denatured proteins or enzymes [23,24] through effect on the synthesis of amino acids, proteins, lipoproteins, and coenzymes according with the formation of stable complexes. The antibacterial activity of chitosan Schiff base metal complexes [Cu(II), [25,26] Ag (II), [27,28] Zn(II) [29] ] against E. coli, S. aureus, salmonella, and B. subtilis was significantly higher than that of free ligand, and increased with the increase of the minimum concentration. [30,31] It only needs small concentration to achieve good antibacterial effect.…”