8‐isoprostanes and resistin as markers of vascular damage in non‐hypersomnolent obstructive sleep apnoea patients

Cherneva, Radostina; Cherneva, Zheina; Georgiev, Ognian; Петрова, Даниела; Petrova, Jordanka

doi:10.1111/cpf.12361

Cited by 13 publications

(7 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…8-Isoprostane is a product of the oxidation of arachidonic acid and is considered to be a reliable marker of oxidative stress because of its chemical stability [50]. Urinary excretion of 8-isoprostane was higher in OSA patients compared with healthy individuals [51]. Advanced glycation end-products (AGE) are the results of the nonenzymatic glycation of proteins.…”

Section: Pregnancy-associated Plasma Protein-a Pregnancyassociated Plasma Protein-a (Pappmentioning

confidence: 99%

Oxidative Stress Markers among Obstructive Sleep Apnea Patients

Stanek

Brożyna-Tkaczyk

Myśliński

2021

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Obstructive sleep apnea (OSA) is a chronic respiratory disorder, which can be present in up to 50% of the population, depending on the country. OSA is characterized by recurrent episodes of partial or complete obstruction of the upper airways with consistent movement of the respiratory musculature during sleep. Apneas and hypopneas can lead to a decrease in oxygen saturation, an increase in carbon dioxide in the blood, and subsequent arousals and sleep fragmentation caused by repetitive activation of the central nervous system. As a consequence, intermittent hypoxemia and consequent reoxygenation result in the production of reactive oxygen species, leading to systematic oxidative stress, which is postulated to be a key mechanism of endothelial dysfunction and increased risk for cardiovascular disorders in patients with OSA. In this review, various biomarkers of oxidative stress, including high-sensitivity C-reactive protein, pregnancy-associated plasma protein-A, superoxide dismutase, cell-free DNA, 8-hydroxy-2-deoxyguanosine, advanced oxidation protein products, lipid peroxidation products, receptor for advanced glycation end-products, and thioredoxin are discussed. Biomarkers of oxidative stress have the potential to be used to assess disease severity and treatment response. Continuous positive airway pressure (CPAP) is one of the most common noninvasive treatments for OSA; it keeps the upper airways open during sleep. This reduces episodes of intermittent hypoxia, reoxygenation, and arousal at night. CPAP has been shown to have anti-inflammatory properties and decrease oxidative stress. The administration of certain compounds, like vitamins A, C, and E as well as N-acetylcysteine and allopurinol, can decrease oxidative stress markers. However, their role in the treatment of OSA remains unclear.

show abstract

Section: Pregnancy-associated Plasma Protein-a Pregnancyassociated Plasma Protein-a (Pappmentioning

confidence: 99%

Oxidative Stress Markers among Obstructive Sleep Apnea Patients

Stanek

Brożyna-Tkaczyk

Myśliński

2021

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

show abstract

“…Orexin‐producing cells have been shown to be inhibited by leptin but activated by ghrelin. These two hormones (resistin and orexin) have been studied more in animal experiments than in clinical trials 75–82 . The current study only found three articles for resistin 31,37,39 and one article for orexin 35 .…”

Section: Discussionmentioning

confidence: 71%

Associations of short sleep duration with appetite‐regulating hormones and adipokines: A systematic review and meta‐analysis

et al. 2020

View full text Add to dashboard Cite

In the current study, a systematic review and meta-analysis were conducted to summarize and assess whether short sleep duration is associated with appetite-regulating hormones and adipokine levels. Reference databases were searched for studies related to sleep and appetite-regulating hormones and adipokines. Qualitative and quantitative syntheses were conducted to evaluate the relationship between sleep duration and the level of appetite-regulating hormones and adipokines, including leptin, ghrelin, adiponectin, resistin, and orexin. Twenty-one of 3536 studies, covering a total of 2250 participants, met the inclusion criteria. Leptin, ghrelin, and adiponectin were included in the meta-analysis. Ghrelin levels were higher in the short sleep group (standard mean difference [SMD] = 0.14, 95% CI [0.03, 0.25], p = 0.01). Significant differences between the short sleep group and recommended sleep group were also noted in leptin level experimental subgroup studies (SMD = 0.19, 95% CI [0.03, 0.35], p = 0.02) and ghrelin level cross-sectional subgroup studies (SMD = 0.14, 95% CI [0.02, 0.27], p = 0.03). A rise in leptin and ghrelin levels were also observed in sleep deprivation groups (SMD = 0.24, 95% CI [0.10, 0.39], p = 0.001 and SMD = 0.18, 95% CI [0.04, 0.33], p = 0.01, respectively). In conclusion, short sleep duration is associated with an increased ghrelin level, while sleep deprivation had a significant effect on the levels of both leptin and ghrelin.

show abstract

“…In accord with our findings on plaque 3-NT, they reported that urinary 8-isoprostane, a marker of oxidative stress, was significantly higher in those patients with OSA. However, there was no statistically significant difference between the groups in resistin—a plasma marker of inflammation ( 39 ). Similarly, most inflammatory cellular markers we investigated did not differ between the groups, although non-significant trends toward higher levels in the neutrophil elastase ( p <0.07) and macrophage-derived foam cells (CD163+/CD68+) in patients with SDB were observed.…”

Section: Discussionmentioning

confidence: 99%

Markers of Carotid Plaque Destabilization in Patients With Sleep-Disordered Breathing

2022

View full text Add to dashboard Cite

Sleep-disordered breathing (SDB) is a nightly respiratory condition characterized by intermittent hypoxia, leading to oxidative stress, inflammation, and atherosclerosis. However, most cellular markers of human carotid plaques in SDB have not yet been assessed. We aimed at characterizing the cellular, inflammatory, and nitro-oxidative stress markers in carotid plaques obtained from 25 patients undergoing endarterectomy and screened for SDB. Sleep studies were performed during their preoperative hospitalization night using the Watch-PAT 100 device. Oxygen desaturation index (ODI) was used for dividing patients into two groups. Fourteen patients with ODI >5 were designated as SDB and 11 patients with ODI ≤ 5 as non-SDB. Demographics, comorbidities, cardiovascular risk factors, and medications were recorded. Cellular markers in plaques were analyzed by immunofluorescence using confocal microscopy. The expression of neutrophils was identified by CD66b+ and neutrophil elastase, macrophage-foam cells were identified by CD163+, and scavenger receptors by CD68+ and CD36+ expression. Additional markers included 3-nitrotyrosine, endothelial CD31, and smooth muscle cell-actin (SMC-actin). Plaques' lipids were determined by immunohistochemistry with Oil Red O staining. Notably, significantly higher values were found for SDB as compared to patients with non-SDB for 3-nitrotyrosine (p <0.004) and intracellular lipids' content (p <0.02), whereas SMC-actin was lower (p <0.006). There were no significant differences between patients with carotid-associated symptoms (symptomatic) and patients without carotid-associated symptoms (asymptomatic). However, a sub-group of symptomatic patients with co-existent SDB expressed the highest 3-nitrotyrosin, and intracellular lipids levels, and the lowest SMC-actin levels, whereas non-SDB/asymptomatic patients expressed the lowest 3-nitrotyrosin and lipids levels and the highest SMS-actin levels among all patients. Accordingly, ODI was lowest in non-SDB/asymptomatic patients and highest in SDB/symptomatic. In conclusion, plaques of patients with SDB were characterized by markedly increased levels of 3-nitrotyrosine and intracellular lipids content. Conversely, SMC-actin levels were significantly lower. These three markers, such as increased 3-nitrotyrosine and intracellular lipids and decreased SMC-actin are associated with plaque vulnerability and instability. These findings are in line with earlier reports demonstrating increased intima-media thickness in large cohorts of sleep apnea and patients with SDB, and thus, may indicate a higher susceptibility to plaque vulnerability and rapture in patients with SDB.

show abstract

8‐isoprostanes and resistin as markers of vascular damage in non‐hypersomnolent obstructive sleep apnoea patients

Cited by 13 publications

References 41 publications

Oxidative Stress Markers among Obstructive Sleep Apnea Patients

Oxidative Stress Markers among Obstructive Sleep Apnea Patients

Associations of short sleep duration with appetite‐regulating hormones and adipokines: A systematic review and meta‐analysis

Markers of Carotid Plaque Destabilization in Patients With Sleep-Disordered Breathing

Contact Info

Product

Resources

About