8-OH-DPAT in the median raphe nucleus decreases while in the medial septal area it may increase anxiety in female rats

Almeida, Rosa M. M. de; Giovenardi, Márcia; Charchat, Helenice; Lucion, Aldo Bolten

doi:10.1016/s0149-7634(98)00026-8

Cited by 47 publications

(32 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A different picture emerges when the effects of drugs acting on 5-HT are considered. Thus, in agreement with the effect of 8-OH-DPAT on the elevated T-maze inhibitory avoidance task, it has been shown that intra-MRN injection of this agonist reduces the expression of anxiety-related behaviors in various animal models such as the elevated plusmaze (File et al 1996;De Almeida et al 1998), the social interaction test (File et al 1996), the black-white transition test, the conditioned suppression of drinking (Carli and Samanin 1988), and contextual fear conditioning (Avanzi and Brandrão2001). As also observed in the present analysis, this anxiolytic effect was achieved at doses that do not consistently change the general motor activity of the animals.…”

Section: Discussionsupporting

confidence: 61%

Serotonergic neurons in the median raphe nucleus regulate inhibitory avoidance but not escape behavior in the rat elevated T-maze test of anxiety

2004

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 61%

Serotonergic neurons in the median raphe nucleus regulate inhibitory avoidance but not escape behavior in the rat elevated T-maze test of anxiety

2004

View full text Add to dashboard Cite

show abstract

“…The behavioral observations during training in the passive avoidance task did not indicate changes in nociceptive thresholds after intraseptal (R)-8-OH-DPAT. However, there were behavioral indications of an anxiogenic-like effect in the (R)-8-OH-DPAT-treated rats, consistent with earlier findings obtained in the elevated plus maze using mice and rats (De Almeida et al, 1998;Micheau and Van Marrewijk, 1999). In contrast, another study performed in rats failed to find any effect on anxiety in the elevated plus maze after intraseptal 8-OH-DPAT, while an anxiolytic-like effect was observed in the shock-probe burying test (Menard and Treit, 1998).…”

Section: Figuresupporting

confidence: 90%

5‐HT_1A and NMDA receptors interact in the rat medial septum and modulate hippocampal‐dependent spatial learning

et al. 2009

View full text Add to dashboard Cite

Cholinergic and GABAergic neurons in the medial septum/vertical limb of the diagonal band of Broca (MS/vDB) projecting to the hippocampus, constitute the septohippocampal projection, which is important for hippocampal-dependent learning and memory. There is also evidence for an extrinsic as well as an intrinsic glutamatergic network within the MS/vDB. GABAergic and cholinergic septohippocampal neurons express the serotonergic 5-HT(1A) receptor and most likely also glutamatergic NMDA receptors. The aim of the present study was to examine whether septal 5-HT(1A) receptors are important for hippocampal-dependent long-term memory and whether these receptors interact with glutamatergic NMDA receptor transmission in a manner important for hippocampal-dependent spatial memory. Intraseptal infusion of the 5-HT(1A) receptor agonist (R)-8-OH-DPAT (1 or 4 microg/rat) did not affect spatial learning in the water maze task but impaired emotional memory in the passive avoidance task at the higher dose tested (4 microg/rat). While intraseptal administration of (R)-8-OH-DPAT (4 microg) combined with a subthreshold dose of the NMDA receptor antagonist D-AP5 (1 microg) only marginally affected spatial acquisition, it produced a profound impairment in spatial memory. In conclusion, septal 5-HT(1A) receptors appears to play a more prominent role in emotional than in spatial memory. Importantly, septal 5-HT(1A) and NMDA receptors appear to interact in a manner, which is particularly critical for the expression or retrieval of hippocampal-dependent long-term spatial memory. It is proposed that NMDA receptor hypofunction in the septal area may unmask a negative effect of 5-HT(1A) receptor activation on memory, which may be clinically relevant.

show abstract

“…They also provided arguments indicating that these anxiogenic effects may facilitate memory performance. In rats, a comparable effect was found in females at a dose of 0.5 µg, but nothing was observed when the dose was lower (0.2 µg) or higher (2 µg) (De Almeida et al 1998). Additionally, in males, Menard and Treit (1998) found no effect in the elevated plus maze, but an anxiolytic-like effect was observed in the shock-probe burying test (Menard and Treit 1998).…”

Section: Effects On Anxietymentioning

confidence: 94%

“…For instance, septal injections of 8-OH-DPAT increase maternal aggressive behaviour (De Almeida and Lucion 1997), influence anxiety (De Almeida et al 1998;Menard and Treit 1998;Micheau and Van Marrewijk 1999) and induce antidepressant-like effects (Martin et al 1990(Martin et al , 1991Schreiber and De Vry 1993). Concerning spatial memory, we previously showed that intraseptal injections of 8-OH-DPAT impaired reference-memory performance in the water maze (Bertrand et al 2000).…”

Section: Introductionmentioning

confidence: 98%

Intraseptal injection of the 5-HT1A/5-HT7 agonist 8-OH-DPAT and working memory in rats

Jeltsch

Bertrand²,

Galani³

et al. 2004

Psychopharmacology

View full text Add to dashboard Cite

These results extend those of a previous experiment which showed that intraseptal injections of 8-OH-DPAT impaired spatial reference memory. Based on the characteristics of the observed deficits, it is suggested that the 8-OH-DPAT-induced impairment, rather than being only the result of a true alteration of working memory, might reflect a more global cognitive deficiency in which alteration of general memory capacities may be biased by disrupted search strategies/exploration and/or dysfunctions of attention.

show abstract

8-OH-DPAT in the median raphe nucleus decreases while in the medial septal area it may increase anxiety in female rats

Cited by 47 publications

References 28 publications

Serotonergic neurons in the median raphe nucleus regulate inhibitory avoidance but not escape behavior in the rat elevated T-maze test of anxiety

Serotonergic neurons in the median raphe nucleus regulate inhibitory avoidance but not escape behavior in the rat elevated T-maze test of anxiety

5‐HT_1A and NMDA receptors interact in the rat medial septum and modulate hippocampal‐dependent spatial learning

Intraseptal injection of the 5-HT1A/5-HT7 agonist 8-OH-DPAT and working memory in rats

Contact Info

Product

Resources

About

8-OH-DPAT in the median raphe nucleus decreases while in the medial septal area it may increase anxiety in female rats

Cited by 47 publications

References 28 publications

Serotonergic neurons in the median raphe nucleus regulate inhibitory avoidance but not escape behavior in the rat elevated T-maze test of anxiety

Serotonergic neurons in the median raphe nucleus regulate inhibitory avoidance but not escape behavior in the rat elevated T-maze test of anxiety

5‐HT1A and NMDA receptors interact in the rat medial septum and modulate hippocampal‐dependent spatial learning

Intraseptal injection of the 5-HT1A/5-HT7 agonist 8-OH-DPAT and working memory in rats

Contact Info

Product

Resources

About

5‐HT_1A and NMDA receptors interact in the rat medial septum and modulate hippocampal‐dependent spatial learning