8-year Analysis of the Prevalence of Lymph Nodes Metastasis, Oncologic and Pregnancy Outcomes in Apparent Early-Stage Malignant Ovarian Germ Cell Tumors

Chatchotikawong, Usanee; Ruengkhachorn, Irene; Leelaphatanadit, Chairat; Phithakwatchara, Nisarat

doi:10.7314/apjcp.2015.16.4.1609

Cited by 7 publications

(4 citation statements)

References 16 publications

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“…However, retroperitoneal metastatic lymph nodes become a difficult problem to treat [22][23][24][25]. These lymph nodes can contribute to metastatic spread, thereby affecting the long-term survival of patients [4,5,[26][27][28][29][30]. 125 I brachytherapy, with a higher local concentration of radiotherapy, is particularly well suited for the treatment of retroperitoneal metastasis [31][32][33][34].…”

Section: Discussionmentioning

confidence: 99%

Clinical efficacy and prognostic factors of CT-guided 125I brachytherapy for the palliative treatment of retroperitoneal metastatic lymph nodes

et al. 2020

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Background: Due to the unique anatomical location of retroperitoneal metastatic lymph nodes, current treatment options are limited. This study was designed to explore the clinical efficacy and prognostic factors of CT-guided 125 I brachytherapy for the treatment of retroperitoneal metastatic lymph nodes. Methods:We retrospectively evaluated 92 patients received 125 I brachytherapy for retroperitoneal metastatic lymph nodes. A layered Cox proportional hazards model was established to filter out the independent factors affecting local tumor progression-free survival (LTPFS).Results: The median LTPFS was 8 months. Metastatic lymph node with uniform density (p-0.009), clear boundaries (p-0.011), regular morphology (P < 0.001), and < 3 organs at risk of metastasis (p-0.020) were associated with better LTPFS. Necrotic lymph nodes (p < 0.001), fusion (p-0.003), and invasion of vessels visible on images (p < 0.001) were associated with poor LTPFS. Puncture path through abdominal wall or paravertebral approach were also associated with better LTPFS than a hepatic approach (P < 0.05). A maximum diameter ≤ 3 cm (P-0.031) or 3-5 cm (P-0.018) were also associated with significantly better LTPFS than a maximum diameter ≥ 5 cm. The Cox proportional hazards model suggested that lymph nodes invaded the large vessels visible on images, maximum diameter and puncture path were independent risk factors for LTPFS.Conclusion: CT-guided 125 I brachytherapy is an optional palliative treatment modality for retroperitoneal metastatic lymph nodes, which can provide high local control without severe complications. Better preoperative planning, intraoperative implementation, better choice of puncture path, and selection of appropriate tumor size are important factors that can improve the clinical efficacy of 125 I brachytherapy for retroperitoneal metastatic lymph nodes.

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Section: Discussionmentioning

confidence: 99%

Clinical efficacy and prognostic factors of CT-guided 125I brachytherapy for the palliative treatment of retroperitoneal metastatic lymph nodes

et al. 2020

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“…However, minimal invasive techniques are characterized by increased operating times, increased cost, but also less postoperative pain, fewer adverse events of surgery, and a shorter length of stay in hospital (23, 24). Moreover, Chatchotikawong et al (25) showed in an eight-year analysis that bilateral pelvic and paraaortic lymphadenectomy could offer information regarding disease extension and prognosis, elimination of some microscopic tumors, and clarify the further treatment options postoperatively. As Brown et al (26) mentioned the lack of full surgical staging could lead to limited tissue evaluation and inappropriate over- or under-treatment options.…”

Section: Discussionmentioning

confidence: 99%

Fertility sparing approach as the standard of care in young patients with immature teratomas

Iavazzo

Vorgias

Iavazzo

et al. 2017

J Turkish German Gynecol AssocJ Turkish German Gynecol Assoc

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Immature teratomas are quite rare tumors arising in young women. They are usually diagnosed in early stage and grade and have a good prognosis. In these young patients, fertility-sparing management is suggested as the standard of care. Bilateral immature teratoma is a rare condition with an incidence of 10%, with a five-year survival rate of 80%. The majority of patients received fertility-sparing treatment followed by adjuvant chemotherapy in 78%. Older age, advanced stage, and high grade are negative prognostic factors. The surgery-only, watch-and-wait approach was evaluated; however, after a median follow-up time of 42 months, 50% of patients experienced recurrence, but they were successfully salvaged with chemotherapy. In a retrospective study, 12 out of 27 patients tried to conceive, resulting in 10 pregnancies (8 after chemotherapy). We present a narrative review of the current literature regarding the essential multidisciplinary approach of such patients in order to achieve the best oncologic and fertility-sparing outcome.

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“…3 Lymph node metastasis found in 28% of patients with ovarian dysgerminoma and was an independent predictor of poor survival. 4 On germinal ovarian cancer, dysgerminoma is most frequently relately with nodal metastasis.…”

Section: Introductionmentioning

confidence: 99%

2 cases dysgerminoma with micrometastasis in lymph nodes

Valdespino¹,

Montenegro²,

Hernandjez³

et al. 2019

OGIJ

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8-year Analysis of the Prevalence of Lymph Nodes Metastasis, Oncologic and Pregnancy Outcomes in Apparent Early-Stage Malignant Ovarian Germ Cell Tumors

Cited by 7 publications

References 16 publications

Clinical efficacy and prognostic factors of CT-guided 125I brachytherapy for the palliative treatment of retroperitoneal metastatic lymph nodes

Clinical efficacy and prognostic factors of CT-guided 125I brachytherapy for the palliative treatment of retroperitoneal metastatic lymph nodes

Fertility sparing approach as the standard of care in young patients with immature teratomas

2 cases dysgerminoma with micrometastasis in lymph nodes

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