801. Triterpenoids. Part XXII. The constitution and stereochemistry of masticadienonic acid

Modulation of Cellular Response to Cisplatin by a Novel Inhibitor of DNA Polymerase β

“…The active compound was found to be MA (3-oxotirucalla-7,24-dien-26-oic acid), for which the structure (Fig. 1C) was known (Barton and Soane, 1956). It is noteworthy that the isomer isomasticadienonic acid, also present in the extract, which only differs by the position of the double bond in ring B (⌬7 versus ⌬8), is totally inactive in the test (data not shown).…”

Anti-ulcer activity of Cyrtocarpa procera analogous to that of Amphipterygium adstringens, both assayed on the experimental gastric injury in rats

“…From the hexane extract of Amphipterygium adstringens, two pentacyclic triterpenes were isolated, characterized, and identified as masticadienonic acid (1) and 3␣-hydroximasticadienonic (3) and ␤-sitosterol (4) and a mixture of unidentified fatty acids were isolated (5) from Cyrtocarpa procera ( Table 3). The identification of compounds was made by comparing their physical and spectroscopic constants with those described in the literature (Barton and Seoane, 1956;Soriano-García et al, 1987;Nguyen et al, 2004;Oliveira et al, 2004;Ai-li and Chang-hai, 2006). Significant variations in yields 1 and 2 were found to depend on the gender of the tree analyzed (t = −3.25, 4 d.f., P = 0.03).…”

Chios Mastic Gum and Its Food Applications

“…The chemical composition of triterpenes of both neutral and acidic fraction has been reported by several authors (Barton and Seoane 1956 ; Monaco et al 1973 ;Mills and White 1989 ;Marner et al 1991 ;Stern et al 2003 ;Papageorgiou et al 1997 ;Colombini et al 2000 ;Dietemann et al 2001 ;. The major constituents are isomasticadienonic acid, masticadienonic acid, and 28-norolean-17-en-3-one.…”