2015
DOI: 10.1071/rdv27n1ab81
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81 Jak-Stat Signalling Is Critical for Inner Cell Mass Development in Bovine Blastocysts

Abstract: The inner cell mass (ICM) of mammalian blastocysts comprises 2 transient lineages, namely hypoblast and epiblast, which develop into extra-embryonic and embryonic tissues, respectively. In the mouse, epiblast cells autocrinally secrete fibroblast growth factor (FGF) to induce hypoblast differentiation, and pharmacological FGF/mitogen-activated protein kinase (MAPK) signal inhibition converts all ICM cells into epiblast. We conducted a chemical screen for additional signal enhancers of epiblast identity in bovi… Show more

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“…JAK/STAT3 (Dreesen & Brivanlou, ) and PI3K (Takahashi, Murakami, & Yamanaka, ) signalling pathways play important roles in maintaining mESCs pluripotency, while TGFβ (Sato et al., ), NF/κB and MAPK/ERK (Armstrong et al., ) signalling pathways are involved in maintaining hESCs in an undifferentiated state. Moreover, JAK/STAT3 activation is required for bovine ICM formation (Meng, Forrester‐Gauntlett, Henderson, & Oback, ) and acquisition of naive pluripotency markers (Meng, Forrester‐Gauntlett, Turner, Henderson, & Oback, ).…”
Section: Discussionmentioning
confidence: 99%
“…JAK/STAT3 (Dreesen & Brivanlou, ) and PI3K (Takahashi, Murakami, & Yamanaka, ) signalling pathways play important roles in maintaining mESCs pluripotency, while TGFβ (Sato et al., ), NF/κB and MAPK/ERK (Armstrong et al., ) signalling pathways are involved in maintaining hESCs in an undifferentiated state. Moreover, JAK/STAT3 activation is required for bovine ICM formation (Meng, Forrester‐Gauntlett, Henderson, & Oback, ) and acquisition of naive pluripotency markers (Meng, Forrester‐Gauntlett, Turner, Henderson, & Oback, ).…”
Section: Discussionmentioning
confidence: 99%
“…Pluripotent TFs Nanog programs and maintains pluripotency of naïve ES cells at the target locus Esrrb synergizing with Oct4–Sox2 binding motifs ( 132 ). Nanog levels in the ICM are stimulated by adenylate cyclase and are downregulated in JAK/STAT pathways ( 133 ). In complexes with 5mC hydroxylases TET1/2, Nanog determines cell fate and pluripotency of ES cells and CSCs ( 131 , 134 ) and implements tissue specificities of genes Brca1 (modulator of cellular stress/repair), Trp53 (tumor repressor), and Rb1 (retinoblastoma suppressor) ( 135 , 136 ).…”
Section: Epigenetics Of the Zygotementioning
confidence: 99%