82-P

Jawdat, Dunia; Alarifi, M.; Al-Turki, Abdulrahman; Alalwan, Abdulaziz; Atallah, N.; Muallimi, Meshal Al; Balwi, Mohammed Al; Hajeer, Ali

doi:10.1016/j.humimm.2013.08.157

Cited by 3 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is indicated that the distribution of CCR5-∆32 is very low in the south of Middle East and also Arabic countries. According to our study, we observed a low frequency of mutant allele in Iran that it is in almost agreement with the result observed from countries such as Saudi Arabia, and India (1%) [38, 39]. The frequency of CCR5-∆32 allele was indicated in Turkey (3.17%), Afghanistan (3.86%), Pakistan (2.86%) [40, 41].…”

Section: Discussionsupporting

confidence: 90%

Prevalence of CCR5delta32 in Northeastern Iran

et al. 2019

View full text Add to dashboard Cite

Background: A 32-base pair deletion (Δ32) in the open reading frame (ORF) of CC motif chemokine receptor 5 (CCR5) seems to be a protective variant against immune system diseases, especially human immunodeficiency virus type 1 (HIV-1). We aimed to assess the frequency of CCR5Δ32 in the healthy Iranian population. Methods: In this study, 400 normal samples from Khorasan, northeastern Iran, were randomly selected. The frequency of CCR5Δ32 carriers was investigated using PCR analysis. Allele prevalence and the fit to the Hardy-Weinberg equilibrium were analyzed. Results: The prevalence of CCR5Δ32 in the northeastern population of Iran was 0.016. Four hundred samples were studied, among which one with CCR5 Δ32/Δ32 and 11 with CCR5 Wild/Δ32 genotype were detected. Conclusion: This study was the first investigation for an assessment of the prevalence of CCR5Δ32 in northeastern Iran. The low prevalence of CCR5Δ32 allele in the Iranian population may result in the increased susceptibility to HIV-1. In addition, this prevalence is the same as that of reported in East Asia, while is lower than that in the Europeans.

show abstract

Section: Discussionsupporting

confidence: 90%