827. Some anti-microbial compounds in the heterocyclic series. Part III. Basic ethers of the benzothiazole and benzoxazole series

Abstract

Solvents for crystallisation were: A, light petroleum (b. p. 60-80"); B, ethanol; C, methanol; * Picrate, m. p. 169-170°; base purified by distillation, b. p. 200"/0.25 mm. t Pzep. from ethiodide by use of ion-exchange resin (De-acidite F.F.). The tartrate, m. p. 76-80 , showed maximum solubility in water at 60'. 3 Morpholino. 7 Distilled, b. p. 219-221"/0.4 mm.; hydrochloride, m. p. 205-207". ** With decornp. D, water; E , propan-2-01. 5 -ChZoro -2 -[4 -(3 -diethyZamino~ropoxy)phenyl]benzothiazoZe HydrochZoride.-2 -Amino-4-

The Quantitative Structure-Activity Relationships of Antifungal Active 2- (p-Substituted-Phenyl) Benzoxazole Derivatives Against Candida Albicans Using The Combinations of Some Hydrophobic, Electronic

“…It was reported by David et al that five-membered heterocycles condensed with 2 benzene rings were chemotherapeutically active (17). Antimicrobial active 2-phenyl benzoxazole derivatives having 2 benzene rings and a 5 membered heterocycle are in agreement with that postulate (6)(7)(8)(9)(18)(19)(20)(21)(22).…”

Investigation of triplet states of 2-(2-hydroxyphenyl)benzothiazole and 2-(2-hydroxyphenyl)benzoxazole by transient absorption spectroscopy and ab initio calculations

“…MHBT was synthesized from 2-hydroxy-6-methylbenzaldehyde according to a procedure similar to that reported by Cossey Nagaoka et al et al 49 2-Hydroxy-6-methylbenzaldehyde was prepared from OHBA.50 A mixture of 2-hydroxy-6-methylbenzaldehyde (2.46 g) and 2-aminobenzenethiol (2.5 g) in excess nitrobenzene (20 g) was refluxed for 3 h. Nitrobenzene was an oxidizing agent.…”

Basic ethers of 2-anilinobenzothiazoles and 2-anilinobenzoxazoles as potential antidepressants

“…An appropriate phenol in acetone with anhyd K2CO 3 was alkylated with a diethylaminoalkyl chloride. 19 Dj. As in D but using EtOH-NaOEt as the medium.19…”