In this study, a one-side zero-azimuth anchoring in-plane switching (OZ-IPS) liquid crystal display (LCD) employing poly(n-hexyl methacrylate) (PHMA) bottlebrush polymers as an application-type zero-azimuth anchoring material was successfully developed. The twist anchoring coefficient A 2 measured for the nematic liquid crystal (NLC) on the PHMA bottlebrush at 25 °C was comparable to that of the same NLC on high-density PHMA brushes. Optimizing the optical design increased the transmission efficiency (TE) of the OZ-IPS cell with the negative NLC to 95%, which was significantly higher than that of conventional IPS cells. Using optical simulation, the OZ-IPS LCDs with a negative NLC clearly exhibited the highest TE (;107% of TN LCDs) for LCDs developed thus far. Moreover, the higher transmittance of the OZ-IPS LCDs was also confirmed for the practical TFT LCD, which exhibited a maximum luminance that was 30% higher than conventional IPS TFT LCDs.