830‐nm irradiation increases the wound tensile strength in a diabetic murine model*

Stadler, István; Lanzafame, Raymond J.; Evans, Ryan; Narayan, Vikram; Dailey, Brian; Buehner, Norene; Naim, John O.

doi:10.1002/lsm.1042

Cited by 143 publications

(101 citation statements)

References 25 publications

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“…the subgroups not given laser treatment presented lower and statistically significant mean collagen percentages, in comparison with the treated subgroups. These results corroborate studies 5,8,11,12,13 in which laser treatment accelerated the wound healing process, with increased production of collagen, a substance that is essential for wound repair. When the results obtained from the control subgroups were analyzed and compared, it was observed that the treated non-diabetic subgroup presented a higher and statistically significant collagen fiber percentage, in comparison with the untreated diabetic subgroup.…”

Section: Discussionsupporting

confidence: 89%

“…We believe that this alteration in healing response may be explained by the action of the laser, as reported by several researchers. 6,8,11,12 Analysis of the results from the fourteenth days after wounding showed increased mean collagen percentages in comparison with the seventh day. However, only the nondiabetic group presented a statistically significant result.…”

Section: Discussionmentioning

confidence: 96%

“…The proposal to analyze tissue repair in diabetic rats was based on the vast literature that reports the healing difficulties caused by diabetes mellitus 6,7,8 . Insulin deficiency syndrome can be obtained experimentally in rats by surgery or by administering diabetes-inducing drugs such as alloxan and streptozotocin.…”

Section: Discussionmentioning

confidence: 99%

“…This has been confirmed by several authors. 6,8,9 Rats with diabetes induced by alloxan produce less granulation tissue than do normal rats. The scars on such animals show weak mechanical resistance, and these alterations have been attributed to biochemical alterations in the wound, caused by insulin deficiency syndrome.…”

Section: Discussionmentioning

confidence: 99%

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Analysis of the influence of low-power HeNe laser on the healing of skin wounds in diabetic and non-diabetic rats

Carvalho¹,

Mazzer²,

Reis³

et al. 2006

Acta Cir. Bras.

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Purpose:To study the influence of HeNe laser irradiation on the collagen percentage in surgically-induced skin wounds in rats with and without alloxan-induced diabetes, by morphometric analysis of collagen fibers. Methods: 48 male Wistar rats were used, divided into groups: laser-treated diabetic (group 1); untreated diabetic (group 2); treated non-diabetic (group 3); and untreated non-diabetic (group 4). For groups 1 and 2, diabetes was induced by intravenous injection of alloxan (2,4,5,5, Sigma), into the dorsal vein of the penis, at a rate of 0.1 ml of solution per 100 g of body weight. A wound was made on the back of all the animals. Groups 1 and 3 were treated with HeNe laser (4 J/cm 2 ) for 60 s. One animal from each group was sacrificed on the 3 rd , 7 th and 14 th days after wounding. Samples were taken, embedded in paraffin, stained with hematoxylin-eosin and Masson's trichrome, and morphometrically analyzed using the Imagelab software. The percentages of collagen fibers were determined from the samples from the euthanasia animals. The data were treated statistically using analysis of variance (ANOVA) and the Student t and Kruskal-Wallis tests. The significance level was set at 0.05 or 5%. Results: The results obtained from the samples taken on the third, seventh and fourteenth days after wounding demonstrated that the laser-treated group presented a statistically significant (p<0.05) greater mean quantity of collagen fibers than in the non-treated group, both for diabetic rats (p = 0.0104) and for non-diabetic rats (p = 0.039). Conclusion: The low-power laser (632.8 nm) was shown to be capable of influencing the collagen percentage in skin wounds by increasing the mean quantity of collagen fibers, both for the diabetic and for the non-diabetic group. Key words: Laser Therapy, Low-Level. Wound Healing. Collagen. Rats. RESUMOObjetivo: Estudar, comparativamente, através de análises morfométricas das fibras colágenas, a influência da irradiação com laser HeNe no percentual de colágeno de lesões cutâneas induzidas em ratos diabéticos aloxânico e não diabéticos. Métodos: Foram utilizados 48 ratos Wistar, machos sendo estes divididos em grupos: Grupo 1 diabético tratado com laser, Grupo 2 diabético não-tratado, Grupo 3 não-diabético tratado e Grupo 4 não-diabéticos não-tratados. Nos grupos 1 e 2 diabetes foi induzido por injeção intravenosa (veia dorsal do pênis de Aloxana (2, 4, 5, 6 -Tetraoxypyrimidina; 5 -6 Dioxyuracila) SIGMA, 0.1ml de solução a cada 100 g. de peso corporal. Todos os animais foram submetidos a uma lesão no dorso e os Grupos 1 e 3, foram tratados com laser HeNe com dosagem de 4 J/cm 2 por 36 s. Um animal de cada grupo sofreu eutanásia no 3º, 7º e 14 dias após a lesão e retiradas as amostras que foram emblocadas em parafina, coradas com H.E., Tricrômico de Masson e a analisadas morfométricamente pelo software IMAGELAB . Os dados resultantes foram tratados estatisticamente pela análise de variância (ANOVA), e pelos testes t e Kruskal-Wallis fixou-se em 0,05 ou 5% (a £ 0,05) o nível ...

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Analysis of the influence of low-power HeNe laser on the healing of skin wounds in diabetic and non-diabetic rats

Carvalho¹,

Mazzer²,

Reis³

et al. 2006

Acta Cir. Bras.

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“…Some of the animal studies investigating the effects of LLLT on wound healing have found similar results to the ones found in the in vitro studies, ranging from decreased inflammation and increased collagen and granulation tissue in the wound bed to increased tensile strength and faster epithelization [20][21][22][23].…”

Section: Lllt-mechanism Of Action On Cellular and Tissular Levelsupporting

confidence: 64%

The use of low-level light therapy in supportive care for patients with breast cancer: review of the literature

et al. 2016

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Breast cancer is the most common cancer in women worldwide, with an incidence of 1.7 million in 2012. Breast cancer and its treatments can bring along serious side effects such as fatigue, skin toxicity, lymphedema, pain, nausea, etc. These can substantially affect the patients' quality of life. Therefore, supportive care for breast cancer patients is an essential mainstay in the treatment. Low-level light therapy (LLLT) also named photobiomodulation therapy (PBMT) has proven its efficiency in general medicine for already more than 40 years. It is a noninvasive treatment option used to stimulate wound healing and reduce inflammation, edema, and pain. LLLT is used in different medical settings ranging from dermatology, physiotherapy, and neurology to dentistry. Since the last twenty years, LLLT is becoming a new treatment modality in supportive care for breast cancer. For this review, all existing literature concerning the use of LLLT for breast cancer was used to provide evidence in the following domains: oral mucositis (OM), radiodermatitis (RD), lymphedema, chemotherapy-induced peripheral neuropathy (CIPN), and osteonecrosis of the jaw (ONJ). The findings of this review suggest that LLLT is a promising option for the management of breast cancer treatment-related side effects. However, it still remains important to define appropriate treatment and irradiation parameters for each condition in order to ensure the effectiveness of LLLT.

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Wounds

Bradley

2017

Laser Therapy in Veterinary Medicine

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830‐nm irradiation increases the wound tensile strength in a diabetic murine model*

Abstract: Low-power laser irradiation at 830 nm significantly enhances cutaneous wound tensile strength in a murine diabetic model. Further investigation of the mechanism of LLLT in primary wound healing is warranted.

Cited by 143 publications

References 25 publications

Analysis of the influence of low-power HeNe laser on the healing of skin wounds in diabetic and non-diabetic rats

Analysis of the influence of low-power HeNe laser on the healing of skin wounds in diabetic and non-diabetic rats

The use of low-level light therapy in supportive care for patients with breast cancer: review of the literature

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