836 - Absence of SLC26A9 Results in Chronic Atrophic Gastritis Progressing to Gastric Cancer through the P53/BCL2 Signalling Pathway

Liu, Xuemei; Li, Taolang; Li, Yunhua; Zhu, Jia; Wen, Ge; Jin, Hai; Yuan, Dumin; Seidler, Ursula; Tuo, Biguang

doi:10.1016/s0016-5085(18)30994-6

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“…They cannot only promote the phosphorylation of transcription factors, but also activate signal transduction kinase, which can lead to the combination of amplification and activation or inhibition of transcription factors, and increase the metabolic rate of skeletal muscle, and the key enzymes and muscles of skeletal muscle. Fibrin and so on will have obvious adaptability changes in the exercise process, which can make full use of metabolic related substrates (Liu et al, 2018). Therefore, some scholars have proposed that the transient transcription of specific genes can be rapidly accumulated during the recovery period of each exercise interval, which can improve the adaptability of the cell level induced by exercise training.…”

Section: Introductionmentioning

confidence: 99%

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2021

Pak. J. Pharm. Sci

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By analyzing the effects of P53 inhibitors and ladder climbing exercise on P53 mRNA transcription in skeletal muscle of mice, the application of P53 mRNA in signal transduction mechanism of skeletal muscle cells was studied. Several clean ICR mice were fed for experiment. The experimental mice were divided into groups to analyze the effect of P53 inhibitor on P53 mRNA transcription in gastrocnemius muscle of mice. The mice were randomly divided into The application of P53 mRNA in signal transduction mechanism of skeletal muscle cells was studied, and the corresponding endurance exercise program and ladder climbing training program were designed. According to the research, exercise is to some extent a stimulating factor affecting P53 inhibitor. Endurance training and injection of P53 inhibitor affect P53 mRNA content. Exercise has a benign effect on ICR mice injected with P53 inhibitor. The expression of P53 mRNA in skeletal muscle was significantly affected by climbing training in youth, and decreased by climbing training in old age. However, there was no difference between long-term climbing training and short-term climbing training in the expression of P53 mRNA in skeletal muscle.

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Section: Introductionmentioning

confidence: 99%

Untitled

2021

Pak. J. Pharm. Sci

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836 - Absence of SLC26A9 Results in Chronic Atrophic Gastritis Progressing to Gastric Cancer through the P53/BCL2 Signalling Pathway

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