853 Helicobacter pylori Resistance to Antibiotics in Europe and Its Relationship to Antibiotic Consumption

Mégraud, Françis; Coenen, Samuel; Versporten, Ann; Kist, Manfred; López-Brea, M; Hirschl, Alexander M.; Andersen, Lis Smedegaard; Goossens, Herman; Glupczynski, Youri

doi:10.1016/s0016-5085(12)60549-6

Cited by 251 publications

(470 citation statements)

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“…H. pylori antimicrobial resistance rates, however, increased clearly in the last decade with clarithromycin resistance rates as high as 37 % [13]. Contrary to our initial expectation, we found that clarithromycin resistance rates were as low as 15 % in the present cohort of gastric MALT lymphoma patients which suggests that clarithromycin is still an effective choice in the empiric eradication of H. pylori infection.…”

Section: Discussioncontrasting

confidence: 99%

“…Nevertheless, antimicrobial resistance rates have been increasing dramatically in clinical H. pylori strains. In Europe, resistance rates to the key antimicrobial clarithromycin range between 5.6 and 36.6 %, with Austria leading the table [13]. Evaluation of clinical H. pylori strains for antimicrobial resistance is recommended for patients with treatment failures, as well as those originating from geographic regions with high rates of antimicrobial resistance [4].…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of Clarithromycin-Resistant Helicobacter pylori Strains in Gastric Mucosa-Associated Lymphoid Tissue Lymphoma Patients

et al. 2016

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Gastric MALT lymphoma is closely associated with Helicobacter pylori infection. Bacterial eradication therapy comprising clarithromycin is the first-line treatment in gastric MALT lymphoma patients. However, antimicrobial resistance to clarithromycin has been increasing in Europe, and thus far, it has not been examined in gastric MALT lymphoma patients. Based upon histopathological investigation, 17 adult gastric MALT lymphoma patients were identified to be related with H. pylori infection between 1997 and 2014. Detection of H. pylori infection in these patients and clarithromycin susceptibility testing were performed by 23S rRNA gene real-time PCR. Twelve of the patients were confirmed with H. pylori infection by real-time PCR. Among these patients, only two were found to be infected with clarithromycin-resistant H. pylori strain. In one of them, both the clarithromycin-resistant and sensitive genotype were detected. The rate of clarithromycin resistance was 15.4 %. Clarithromycin resistance pattern in gastric MALT lymphoma patients is under the predictions since a previous study performed in Central Europe revealed a rate of 36.6 % in Austria.Considering the low antimicrobial resistance rate, clarithromycin is still an option in gastric MALT lymphoma management.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prevalence of Clarithromycin-Resistant Helicobacter pylori Strains in Gastric Mucosa-Associated Lymphoid Tissue Lymphoma Patients

et al. 2016

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“…Possibly, the clinical resistance of H. pylori to AMX depends on bioaccessibility of the drug in gastric mucosa linked to its acidity [9]. Our results have been confi rmed by other European data, documenting the level of resistance to amoxicillin of 0-0.9% [11]. A high proportion of primary amoxicillin resistance (13.6-59%) was detected in Africa, Asia and South America [12][13][14].…”

Section: Discussionsupporting

confidence: 87%

Evaluation of antimicrobial resistance of Helicobacter pylori in the last 15 years in West Poland

Karpiński

Andrzejewska

Eder

et al. 2015

Acta Microbiologica et Immunologica Hungarica

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Increasing resistance to drugs represents a serious problem in treatment of infections with Helicobacter pylori, providing cause of frequent therapeutic failures. Present study aimed at analysis of changes in resistance of H. pylori to antibiotics in West Poland within the recent 15 years. 108 strains of H. pylori were analysed, isolated from gastric mucosa of adult patients. Group 1 involved 66 strains isolated in years of 1998/1999. Group 2 comprised 42 isolates obtained in years of 2013/2014. Susceptibility to amoxicillin (AMX), clarithromycin (CL), tetracycline (TC) and metronidazole (MTZ) was determined by E-test (AB Biodisc). All strains on both studied groups were susceptible to AMX. In group 1 all strains proved to be susceptible to TC, while 9% and 36% of tested strains were resistant to CL and MTZ, respectively. By contrast, in group 2, 31% and 83% of strains were resistant to CL and MTZ, respectively. In parallel, 14% strains were found to be resistant to TC (according to EUCAST interpretations). In West Poland, within recent 15 years a dramatic increase was noted in H. pylori strains resistant to metronidazole. In parallel, a signifi cant increase was noted in proportion of strains resistant to clarithromycin.

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“…In a Vietnamese study, clarithromycin resistance, which exceeded 50 % in young children, was a significant cause of treatment failure. The authors suggested that clarithromycin should not be used as part of H. pylori eradication therapy in children if their antibiotic susceptibility profile is unknown [7][8][9][10]. The conclusions of the authors from these aforementioned studies reflect a distinct change in the approach to management of H. pylori infection, which is targeted therapy based on resistance profiles, rather than the disease outcomes.…”

Section: Background and Significancementioning

confidence: 99%

Helicobacter pylori Gastritis: Susceptible to Further Testing?

Rogers

Gold

2016

Dig Dis Sci

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853 Helicobacter pylori Resistance to Antibiotics in Europe and Its Relationship to Antibiotic Consumption

Cited by 251 publications

References 0 publications

Prevalence of Clarithromycin-Resistant Helicobacter pylori Strains in Gastric Mucosa-Associated Lymphoid Tissue Lymphoma Patients

Prevalence of Clarithromycin-Resistant Helicobacter pylori Strains in Gastric Mucosa-Associated Lymphoid Tissue Lymphoma Patients

Evaluation of antimicrobial resistance of Helicobacter pylori in the last 15 years in West Poland

Helicobacter pylori Gastritis: Susceptible to Further Testing?

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