891 Etiology of First Day Hypocalcemia (Fdh): Role of PTH and Calcitonin?

Serum calcitonin concentrations in premature infants during the first 12 weeks of life

“…The significance of this finding is unclear. In early neonatal hypocalcemia of the premature or asphyxiated infant, it appears quite clear that the high elevations of calcitonin are at least partially responsible [3,[5][6][7]. The hypocalcemia and hypophosphatemia associated with demineralization seen in about a fourth of very small prematures at 9-12 weeks of age are contributed to by a 25OHD deficiency [14][15][16].…”

“…Infants of diabetic mothers do not have higher serum calcitonin concentrations [7,8]; however, they may be more sensitive to calcitonin elevations [8] and in this group serum calcitonin and serum calcium are inversely correlated [8].…”

“…Serum phosphorus was normal or low (6.0 _+ 1.4-6.5 --_ 1.0), and serum magnesium was normal (1.7 -+ 0.24-1.8 __-0.34). The reason for the sustained elevation of serum calcitonin in these very small, sick, premature infants in unclear.Key words: Calcitonin --Premature --Osteopenia --Hypocalcemia --Parathyroid hormone.higher serum calcitonin concentrations than normocalcemic infants [6,7]. Infants of diabetic mothers do not have higher serum calcitonin concentrations [7,8]; however, they may be more sensitive to calcitonin elevations [8] and in this group serum calcitonin and serum calcium are inversely correlated [8].…”