899 A Three-gene Expression Signature Model for Risk Stratification of Patients With Neuroblastoma

Garcia, I; Mayol, Gemma; Ríos, José Luis De la Cruz; Cheung, Nai Kong V.; Obertheur, A.; Fischer, M; Jm, Maris; Gm, Brodeur; Jason, M Ridlon; Lavarino, Cinzia

doi:10.1016/s0959-8049(12)71530-7

Cited by 1 publication

(1 citation statement)

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“…Contrary to the adult tumor, we found that higher GSDMB expression neuroblastoma manifested prolonged overall survival. Multiple neuroblastoma prognosis signatures have been made through various methods ( Garcia et al, 2012 ; Zhong et al, 2018 ; Brady et al, 2020 ). These signatures showed excellent predictive performance of neuroblastoma outcomes while less correlated with the neuroblastoma immune landscape.…”

Section: Discussionmentioning

confidence: 99%

Pyroptosis-Related Gene Signature Predicts the Prognosis and Immune Infiltration in Neuroblastoma

Xia

et al. 2022

Front. Genet.

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Neuroblastoma is the most common pediatric extracranial solid tumor. The 5-year survival rate for high-risk neuroblastoma is less than 50%, despite multimodal treatment. Pyroptosis, an inflammatory type of programmed cell death, manifested pro-tumor and anti-tumor roles in the adult tumor. Thus, we aimed to elucidate the function of pyroptosis in neuroblastoma. We classified neuroblastoma patients into two clusters based on the pyroptosis gene expression. We found high pyroptosis neuroblastoma manifested favorable overall survival and more anti-tumor immune cell infiltration. Based on the results of a stepwise Cox regression analysis, we built a four-gene predictive model including NLRP3, CASP3, IL18, and GSDMB. The model showed excellent predictive performance in internal and external validation. Our findings highlight that high pyroptosis positively correlated with neuroblastoma outcomes and immune landscape, which may pave the way for further studies on inducing pyroptosis therapy in high-risk neuroblastoma treatment.

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Section: Discussionmentioning

confidence: 99%