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Abstract

Background: Urinary Tract Infections (UTIs) are one of the most commonly occurring infections in medical practice despite the widespread availability of antibiotics. This study aims to ascertain the prevalence of uropathogens and determine their antibiotic susceptibility or resistance patterns in the Indian population. Methods: A thorough search on the research studies concerning UTIs and their antibiotic susceptibility patterns in India was conducted through electronic databases including Google Scholar, Directory of Open Access Journals, Web of Science, Elsevier, etc. Search results were evaluated for the appropriateness of being included in the study. A total of 12 reports published from different regions of India were involved in the study. Analysis of data was performed using Comprehensive Meta-Analysis (CMA) software. Results: The most commonly isolated uropathogens were observed to be E. coli, and Klebsiella spp., with a prevalence of 49.6% and 12.8%, respectively. The highest mean resistance was found to be towards Ciprofloxacin, followed by Ampicillin. Resistance patterns in E.coli were found to be more towards Ampicillin (74.11%) and followed by Ciprofloxacin (61.32%). In the other uncommon uropathogens, the highest resistance was recorded towards Ampicillin (62.98%) and Ceftriaxone (62.7%). Conclusions: Over the past years, the resistance levels have been increasing gradually to the traditional drugs used for the treatment of UTI, and hence, a therapy based on the individual culture report and antibiotic sensitivity test is highly encouraged. The use of combinational drugs in the treatment of common infections may help reduce the spiking levels of resistance.

Epidemiological Study of the Antimicrobial Resistance Pattern of a Suspected Urinary Tract Infection in a Super Surgical, Super Specialty Hospital in Northern India

“…In a study conducted in Northeast Ethiopia by Adugna and collaborators, it was also found that tetracycline was met with the highest resistance rate, at 65.70%, while colistin was identified as the most effective drug, with a 100.00% success rate against E. coli [21]. Klebsiella pneumoniae showed 100.00% resistance to ceftazidime but high sensitivity to Amikacin (93.33%), colistin (92.86%), and fosfomycin (71.43%), results that are comparable to those from other studies [5,36]. Pseudomonas aeruginosa was highly resistant to ceftazidime and levofloxacin (60.00%) but sensitive to nitrofurantoin, colistin, and aztreonam (100.00%).…”

“…Among UTI cases, Escherichia coli stands out as the leading cause, responsible for approximately 90% of community-reported cases and 50% of hospital-reported cases [2,3]. In addition to E. coli, various other pathogens, such as Klebsiella species, Proteus species, Acinetobacter species, Pseudomonas species, Staphylococcus species, Enterococcus species, and Streptococcus species, have also been identified as uropathogens [4,5]. Frequent UTI symptoms that patients commonly encounter include dysuria, polyuria, and cystitis [6].…”