2011
DOI: 10.1002/bip.21406
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9.3 KDa components of the injected venom of Conus purpurascens define a new five‐disulfide conotoxin framework

Abstract: The 83-residue conopeptide (p21a) and its corresponding non-hydroxylated analog were isolated from the injected venom of Conus purpurascens. The complete conopeptide sequences were derived from Edman degradation sequencing of fragments from tryptic, chymotryptic and cyanogen bromide digestions. p21a has a unique, ten-cystine/5-disulfide 7-loop framework with extended 10-residue N-terminus and a 5-residue C-terminus tails, respectively. p21a has a 48% sequence homology with a recently described 13-cystine conop… Show more

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Cited by 25 publications
(27 citation statements)
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“…These results suggest that each individual cone snail specimen acts as a unique Bpeptide engineer,^producing a distinct blend of bioactive venom components fitted for a specific molecular hunting strategy. In fact, we have shown that some specimens of C. purpurascens express δ-PVIIA as part of their excitatory cabal, whereas other specimens prefer to use p21a for the same purpose [39].…”
Section: Comparison Of the Two Most Dissimilar Injected Venom Profilesmentioning
confidence: 98%
“…These results suggest that each individual cone snail specimen acts as a unique Bpeptide engineer,^producing a distinct blend of bioactive venom components fitted for a specific molecular hunting strategy. In fact, we have shown that some specimens of C. purpurascens express δ-PVIIA as part of their excitatory cabal, whereas other specimens prefer to use p21a for the same purpose [39].…”
Section: Comparison Of the Two Most Dissimilar Injected Venom Profilesmentioning
confidence: 98%
“…79 Enzyme components of cone snail venoms include phospholipase A2-like conodipine-M 80 and glycosyl hydrolases (hyaluronidases). 81,82 It is noteworthy that neuroactive metabolites have recently been demonstrated to be produced by bacteria living in symbiosis with cone snails.…”
Section: Generation Of Peptide Diversitymentioning
confidence: 99%
“…Mature, active Cikot-Cs is a dimer of a covalent dimer (tetramer) (29). Mature Cikot-Cp likely forms a non-covalent dimer and was found with proline as well as hydroxyproline residues in two positions (white arrows) and an amidated His at the C terminus (30). Tryptic peptides identified by mass spectrometry for C. geographus Cikots are boxed.…”
Section: Figmentioning
confidence: 99%
“…Con-ikot-ikot was first isolated from the venom of the fishhunter Conus striatus (29) with a homologous protein subsequently found in the venom of Conus purpurascens (p21a, (30)). The active C. striatus polypeptide is a tetramer (a noncovalent dimer of a covalent dimer) that targets the AMPA (␣-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor, a subtype of the ionotropic glutamate receptor (29).…”
Section: Fig 1 2d Gel Images Of Proteins Extracted From 4 Venom Glamentioning
confidence: 99%