9-[4-Hydroxy-3-(hydroxymethyl)butyl]guanine monohydrate

Tang, Huang; Cheng, Feng-Jie; Li, Nan; Liu, Yancheng; Chen, Zhen-Feng

doi:10.1107/s1600536809043980

Cited by 1 publication

(1 citation statement)

References 8 publications

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“…This stands in strong contrast to the structural data that is currently available of this widely-used drug family. Apart from various crystal structure analyses reported of acyclovir, [10][11][12] very little or no structural data is available for other guanosine nucleoside analogues which are APIs [13][14][15]. This is very surprising given the interest and focus on solid forms of famciclovir; e.g., the occurrence of different crystalline forms of famciclovir during the manufacturing and drying process [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Born out of Fire and Ice: Polymorph Studies of the Antiviral Famciclovir

Vella‐Żarb

Baisch

2021

Crystals

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There is much interest and focus on solid forms of famciclovir. However, in spite of the abundance of reported differences in oral bioavailability, compressibility, and other physical–chemical properties of the various crystal forms of this drug, very little precise structural analysis is available in the literature to date. The form used in the commercial formulation is the anhydrous form I. Patents and patent applications report three different anhydrous crystalline forms on the basis of unindexed powder diffraction patterns. Single-crystal and variable-temperature X-ray diffraction experiments using the commercially available anhydrous form of famciclovir were carried out and led not only to the crystal structure determination of the anhydrous form I, but also to discovery of a new crystal form of anhydrous famciclovir from powder data.

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