9-Hydroxy-2,2,6, 7-tetramethyl-2H-[1]-benzopyran-(1-phenylethylene-10-yl) -[3,2-b]-dihydropyran-4-one from Calophyllum tomentosum

Chemical Constituents of Calophyllum brasiliensis: Structure Elucidation of Seven New Xanthones and Their Cancer Chemopreventive Activity

“…Among the xanthones isolated in this study, 4, 5, 6, and 11 were found to exhibit significant inhibitory activity against 12-Otetradecanoylphorbol-13-acetate induced Epstein-Barr virus early antigen activation in Raji cells.Continuing our search for cancer chemopreventive compounds from plant sources, we examined constituents of Calophyllum brasilienses (Guttiferae) collected in Brazil. Many Calophyllum species have been studied, and xanthones, 2-10 coumarins, 11-19 biflavonoids, 20,21 chalcones, [22][23][24][25] benzofurans, 26 and triterpenoids 27 have been identified as constituents. In a previous paper, we reported the isolation and identification of 26 natural xanthones from plants of the Guttiferae family, such as Garcinia assigu LANTB., Garcinia dulcis (ROXB.)…”

“…Continuing our search for cancer chemopreventive compounds from plant sources, we examined constituents of Calophyllum brasilienses (Guttiferae) collected in Brazil. Many Calophyllum species have been studied, and xanthones, − coumarins, − biflavonoids, , chalcones, − benzofurans, and triterpenoids have been identified as constituents. In a previous paper, we reported the isolation and identification of 26 natural xanthones from plants of the Guttiferae family, such as Garcinia assigu L antb ., Garcinia dulcis (R oxb .)…”

Hexamethoxyamentoflavone trihydrate

“…C. tomentosum is credited with hepato-protective, anti-oxidant and anti-HIV activity and is found as a major constituent in many Ayurved preparations such as Punnaga (Mehrotra et al, 1986). Previous phytochemical investigations of C. tomentosum leaves revealed the presence of triterpenoids, stereoids, xanthonoids, apetaloids and coumarins (Babu et al, 1994;Banerji et al, 1994). As part of a search for novel inhibitors of HIV reverse transcriptase, a methanol extract of C. tomentosum was isolated and converted to the hexamethoxy derivative.…”